FRIDAY Biochem Review Review Flashcards
What partly activates phosphorylase kinase?
Ca2+
How is phosphorylase maximally activated>?
Phosphorylation in response to hormonal signals
What stimulates the activity of phosphofructokinase 1?
AMP
Fructose 2,6-BP
What reduces the activity of phosphofructosekinase-1?
Citrate
ATP
Describe McArdles disease. What type is it? What are the effects?
Type V
Myophosphorylase absence (muscle phosphorylase)
Results in glycogen accumulation and shortage of ATP (high [ADP])
Effects —> muscle weakness, cramping
Describe Hers Disease. What type is it? What are the effects? (Add)
Type VI
(Similar to type I)
Mutated phosphorylase
What is the main driver of smooth muscle contraction?
Calmodulin, calcium bound
What mutations cause Malignant Hyperthermia
Mutations in light chain
Mutations in ryanodine receptors
What encodes a Proteins in type 1 muscle fibers?
MyH7
When treated with trypsin or chymotrypsin what happens with meromysin?
Heavy meromysin —> S1 and S2 region
Light meromysin —> 2 helix chains
Mutations in MYH7 would cause what disfunction in myosin?
Inability for Myosin tails to bind to other myosin tails
What is the role of Dystrophin?
Plays a vital role in ensuring the z - disk attaches to the sarcolemma
Connects cytoskeleton to basal lamina and stabilizes the membrane
“The link”
How is Duchenne muscular dystrophy detected
PCR
What protein is encoded by the biggest gene in the body?
Dystrophin (huge protein, almost as big as titan)
Which troponin type will increase and be found in serum after a heart attack?
Serum levels of TnI will increase one hour after a heart attack
