Nitroglycerin/Nitropaste (Nitrostat) Flashcards
Nitroglycerin/Nitropaste (Nitrostat)
Class
Vasodilator
Nitroglycerin/Nitropaste (Nitrostat)
Mechanism of Action
Smooth muscle relaxant acting on vascular, bronchial, uterine, and intestinal smooth muscle; dilation of arteries and veins in the periphery; reduces preload and afterload; decreases the workload of the heart reducing myocardial oxygen demand.
Nitroglycerin/Nitropaste (Nitrostat)
Indications
Acute angina pectoris, ischemic chest pain, hypertension, CHF, and pulmonary edema.
Nitroglycerin/Nitropaste (Nitrostat)
Contraindicatons
Hypotension, hypovolemia, intracranial bleeding or head injury, previous administration of Viagra, Revatio, Levitra, Cialis, or similar agents within the last 24 hours.
Nitroglycerin/Nitropaste (Nitrostat)
Adverse Reactions
Headache, hypotension, syncope, reflex tachycardia, flushing, nausea, vomiting, diaphoresis, and muscle twitching.
Nitroglycerin/Nitropaste (Nitrostat)
Drug Interactions
Additive effects with other vasodilators; incompatible with other drugs IV.
Nitroglycerin/Nitropaste (Nitrostat) Adult Dosage (Tablets)
Tablets: 0.3 – 0.4 mg SL; may repeat in 5 minutes to a maximum of 3 doses.
Nitroglycerin/Nitropaste (Nitrostat)
Pediatric Dosage
Pediatric: Not recommended
Nitroglycerin/Nitropaste (Nitrostat) Adult Dosage (Paste)
Adult: Paste: 1⁄2 - 1 inch topical
Nitroglycerin/Nitropaste (Nitrostat)
Onset
Onset: 1 – 3 minutes
Nitroglycerin/Nitropaste (Nitrostat)
Peak Effect
Peak effect: 5 – 10 minutes
Nitroglycerin/Nitropaste (Nitrostat)
Duration
Duration: 20 – 30 minutes
Nitroglycerin/Nitropaste (Nitrostat)
Special Considerations
Hypotension is more common in the geriatric population. NTG decomposes if exposed to light or heat. Must be kept in an airtight container.
Nitroglycerin/Nitropaste (Nitrostat)
IV Infusion Dose
IV infusion 10-20 mcg/min, increase by 5-10 mcg q 5 minutes until desired effect.
Nitroglycerin/Nitropaste (Nitrostat)
Transdermal Dose
Transdermal 1-2 cm, 15-30 mg.
