Epi 1:1,000

Question 1

EPI 1:1,000

Class

Answer 1

Sympathomimetic

Question 2

EPI 1:1,000

Mechanism of Action

Answer 2

Bronchial Dilation; Direct-acting alpha- and beta-agonist. Alpha: vasoconstriction. Beta-1: positive inotropic, chronotropic, and dromotropic effects. Beta-2: bronchial smooth muscle relaxation and dilation of skeletal vasculature.

Question 3

EPI 1:1,000

Indications

Answer 3

Allergic reactions, anaphylaxis, and bronchial asthma. Symptomatic bradycardia where patient is not responsive to other interventions.

Question 4

EPI 1:1,000

Contraindications

Answer 4

Hypothermia, tachyarrhythmias, pulmonary edema, myocardial ischemia, hypovolemic shock.

Question 5

EPI 1:1,000

Relative Contraindications

Answer 5

Underlying cardiovascular disease/angina, hypertension, pregnancy, patients over 40 years of age, hyperthyroidism

Question 6

EPI 1:1,000

Adverse Reactions

Answer 6

Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, and angina.

Question 7

EPI 1:1,000

Drug Interactions

Answer 7

Potentiates other sympathomimetics, deactivated by alkaline solutions, (i.e. Sodium bicarbonate), monoamine oxidase inhibitors (MAOIs) may potentiate effects, beta-blockers may blunt effects.

Question 8

EPI 1:1,000
Adult Dosage IM
Allergic Reaction and Asthma

Answer 8

0.3 – 0.5 mg 1:1,000 IM

Question 9

EPI 1:1,000

Continuous Infusion for Bradycardia

Answer 9

Add 1 mg (1 mL of 1:1,000 solution) to 500 mL of NS or D5W. Initial infusion rate of 1 mcg/min titrated to effect (typical dose 2 – 10 mcg/min).

Question 10

EPI 1:1,000

Profound Bradycardia or Hypotension

Answer 10

2 – 10 mcg/min; titrate to patient response.

Question 11

EPI 1:1,000

Pediatric

Answer 11

0.01 mg/kg up to 0.3 mg

Question 12

EPI 1:1,000
Adult Dosage IV
Allergic Reaction and Asthma

Answer 12

SC 0.1-0.3 mg IV.