Magnesium Sulfate Flashcards
Magnesium Sulfate
Adult Dosage
Seizure activity associated with pregnancy:
1 – 4 g IV/IO over 3
minutes; maximum dose of 30 – 40 g/day
Magnesium Sulfate
Adult Dosage
Torsades de pointes or cardiac arrest due to hypomagnesaemia:
1 -2 g diluted in D5W IV/IO over 5 – 20 minutes.
Magnesium Sulfate
Adult Dosage
Torsades de pointes w/ a pulse or AMI w/ hypomagnesaemia:
Loading dose of 1 – 2 g mixed in 50 – 100 mL D5W over 50 – 60 minutes IV. Follow with 0.5 – 1 g/hr IV titrated to effect.
Magnesium Sulfate
Asthma:
1-2 g mixed in 50-100 ml given over 10-20 mins
Magnesium Sulfate
Pediatric for Torsades
IV/IO infusion: 25 – 50 mg/kg over 10 – 20 minutes; faster if
treating Torsade de pointes.
Magnesium Sulfate
Pediatric Dose for asthma:
25 – 50 mg/kg over 10 – 20 minutes
Magnesium Sulfate
Onset IV/ IO
IV/IO immediate
Magnesium Sulfate
Duration IV/ IO
IV/IO 30 minutes
Magnesium Sulfate
Special Considerations
Use with caution in patients with renal failure
Magnesium Sulfate
Onset IM
IM 3 – 4 hours
Magnesium Sulfate
Duration IM
IM 3 -4 hours
Magnesium Sulfate
Class
Electrolyte
Magnesium Sulfate
Mechanism of Action
- Reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction
- manages seizure in toxemia of pregnancy, induces uterine relaxation.
- Can cause bronchodilation after beta-agonists and anticholinergics have been used.
Magnesium Sulfate
Indications
Seizures of eclampsia, torsade de points, hypomagnesaemia
Magnesium Sulfate
Contraindications
Heart blocks, myocardial damage, shock
Magnesium Sulfate
Adverse Reactions
CNS depression, circulatory collapse, facial flushing, diaphoresis, hypotension, decreases reflexes
Magnesium Sulfate
Drug Interactions
May enhance the effects of other CNS depressants, serious changes in overall cardiac function may occur with cardiac glycosides.
