Isoproterinol (Isuprel)

Question 1

Isoproterenol (Isuprel

Class

Answer 1

Sympathomimetic

Question 2

Isoproterenol (Isuprel)

Mechanism of Action

Answer 2

Increase in heart rate and cardiac contractile force, causes bronchodilation

Question 3

Isoproterenol (Isuprel)

Adverse Reactions

Answer 3

Can cause ventricular irritability, deactivated by alkaline solutions, used with caution if MI is suspected.

Question 4

Isoproterenol (Isuprel)

Indications

Answer 4

Bradycardia refractory to atropine and other therapies (last resort), severe status asthmaticus, and poisoning from beta-blockers

Question 5

Isoproterenol (Isuprel)

Contraindications

Answer 5

Should not be used to increase blood pressure in cardiogenic shock

Question 6

Isoproterenol (Isuprel)

Adult Dosage

Answer 6

Adult: 1 mg should be placed in to 500 mL of D5W then slowly infused at 2 – 10 mcg/min and titrated until the desired rate is obtained or until PVCs occur

Question 7

Isoproterenol (Isuprel)

Pediatric Dosage

Answer 7

Pediatric: 0.1 mcg/kg/min

Question 8

Isoproterenol (Isuprel)

Onset

Answer 8

Onset: 1 – 5 minutes Duration: 15 – 30 minutes

Question 9

Isoproterenol (Isuprel)

Duration

Answer 9

Duration: 15 – 30 minutes

Question 10

Isoproterenol (Isuprel)

Special Considerations

Answer 10

Increases myocardial oxygen demand and can induce V- fib and V-tach. May exacerbate tachydysrhythmias due to digitalis toxicity or hypokalemia.