Naloxone (Narcan)

Question 1

Naloxone (Narcan)

Class

Answer 1

Narcotic antagonist

Question 2

Naloxone (Narcan)

Mechanism of Action

Answer 2

Competitive inhibition at narcotic receptor sites, reverses respiratory depression secondary to depressant drugs, completely inhibits the effect of morphine.

Question 3

Naloxone (Narcan)

Indications

Answer 3

Opiate overdose, coma; complete or partial reversal of CNS and respiratory depression induced by opioids, decreased level of consciousness, coma of unknown origin, narcotic agonist for the following, morphine, heroin, hydromorphone (Dilaudid), methadone, Demerol, fentanyl, codeine, Stadol, Talwin, and Nubain.

Question 4

Naloxone (Narcan)

Contraindications

Answer 4

Use with caution in narcotic dependent patients and in neonates of narcotic-addicted mothers.

Question 5

Naloxone (Narcan)

Adverse Reactions

Answer 5

Withdrawal symptoms in the addicted patient, tachycardia, hypertension, arrhythmias, nausea, vomiting, and diaphoresis.

Question 6

Naloxone (Narcan)

Drug Interactions

Answer 6

Incompatible with bisulfate and alkaline solutions.

Question 7

Naloxone (Narcan)

Adult Dosage

Answer 7

0.4 – 2 mg SIVP, IM, SC, or ET; minimum recommended dose is 2 mg; repeat at 5-minute intervals to a maximum dose of 10 mg.

Question 8

Naloxone (Narcan)

Pediatric Dosage

Answer 8

0.1 mg/kg/dose SIVP, IM, SC, and ET to a maximum dose of 0.8 mg; if no response administer an additional 0.1 mg/kg/dose.

Question 9

Naloxone (Narcan)

Onset

Answer 9

within 2 minutes

Question 10

Naloxone (Narcan)

Peak Effect

Answer 10

Variable

Question 11

Naloxone (Narcan)

Duration

Answer 11

30 – 60 minutes

Question 12

Naloxone (Narcan)

Special Considerations

Answer 12

May not reverse hypotension. Use with caution when administering to narcotic addicted patients (potential for violent behavior).