Dopamine

Question 1

Dopamine

Class

Answer 1

Sympathomimetic, inotropic agent

Question 2

Dopamine

Mechanism of Action

Answer 2

Immediate metabolic precursor to norepinephrine. Increases systemic vascular resistance. Causes peripheral vasoconstriction, but dilates renal vasculature at low doses. Increases myocardial contractility and stroke volume.

Question 3

Dopamine

Indication

Answer 3

Cardiogenic, septic or spinal shock, hypotension with low cardiac output states, and distributive shock.

Question 4

Dopamine

Contraindications

Answer 4

Hypovolemic shock, pheochromocytoma, tachyarrhythmias, V-fib.

Question 5

Dopamine

Adverse Reactions

Answer 5

Cardiac arrhythmias, hypertension, increased myocardial oxygen demand; extravasation may cause tissue necrosis.

Question 6

Dopamine

Drug Interactions

Answer 6

Drug interactions: Incompatible with alkaline solutions. MAOIs will enhance the effects of dopamine. Bretylium may potentiate effect of dopamine. Beta- blockers may antagonize the effects of dopamine. When administered with phenytoin; may cause hypotension, bradycardia, and seizures.

Question 7

Dopamine

Adult Dosage

Answer 7

IV infusion at 2 – 20 mcg/kg/min titrated to effect

Question 8

Dopamine

Pediatric Dose

Answer 8

2 – 20 mcg/kg/min titrated to effect

Question 9

Dopamine

Onset

Answer 9

1 – 4 minutes

Question 10

Dopamine

Peak Effect

Answer 10

5 – 10 minutes

Question 11

Dopamine

Duration

Answer 11

Effects stop almost immediately after infusion is stopped

Question 12

Dopamine
Special Consideration
2-5mcg/kg/min

Answer 12

2 – 5 mcg/kg/min: dilates vessels in kidneys; increased urine output.

Question 13

Dopamine
Special Consideration
5-10mcg/kg/min

Answer 13

5 – 10 mcg/kg/min: increased heart rate (beta effects)

Question 14

Dopamine

10-20mcg/kg/min

Answer 14

10 – 20 mcg/kg/min: primarily vasoconstriction (alpha effects)