Neuroreceptors Flashcards
What are ion channels composed of?!
Several subunits
Span the membrane
Channel down the middle
What are the two main types of receptors?!
Metabotropic: G proteins
Ionotropic: ligand gated ion channels
What does ion binding cause?!
Change in conformation
What are the two examples of pentameric ion channels?!
GABA and acetylcholine
What is the example of an ion channel made up of 4 subunits?!
Glutamate
What is nAChR permeable to?!
Potassium, sodium and sometimes calcium ions
What is the nAChR composed of in the brain?!
2 alpha and 3 beta subunits
Why does the NMDA receptor work at a higher frequency?!
At normal transmission it is blocked by a magnesium ion
What binds to AMPA and NMDA receptors?!
Glutamate
When is the magnesium ion expelled from the channel?!
When the membrane depolarises due to the AMPA channel allowing potassium out and sodium in this expels the magnesium ion.
Which domains in the G protein make up the NT binding site?!
2,3,6 and 7
Which domains in G proteins make up the G protein binding site?!
The loop between the 5th and 6th domains
What second messengers are activated by G proteins?!
cAMP and phospholipase C
Which receptor has faster effects?!
Ion channels
What is integration?!
Summation of IPSP’s and EPSP’s