Neuroreceptors Flashcards

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0
Q

What are ion channels composed of?!

A

Several subunits
Span the membrane
Channel down the middle

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1
Q

What are the two main types of receptors?!

A

Metabotropic: G proteins
Ionotropic: ligand gated ion channels

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2
Q

What does ion binding cause?!

A

Change in conformation

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3
Q

What are the two examples of pentameric ion channels?!

A

GABA and acetylcholine

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4
Q

What is the example of an ion channel made up of 4 subunits?!

A

Glutamate

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5
Q

What is nAChR permeable to?!

A

Potassium, sodium and sometimes calcium ions

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6
Q

What is the nAChR composed of in the brain?!

A

2 alpha and 3 beta subunits

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7
Q

Why does the NMDA receptor work at a higher frequency?!

A

At normal transmission it is blocked by a magnesium ion

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8
Q

What binds to AMPA and NMDA receptors?!

A

Glutamate

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9
Q

When is the magnesium ion expelled from the channel?!

A

When the membrane depolarises due to the AMPA channel allowing potassium out and sodium in this expels the magnesium ion.

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10
Q

Which domains in the G protein make up the NT binding site?!

A

2,3,6 and 7

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11
Q

Which domains in G proteins make up the G protein binding site?!

A

The loop between the 5th and 6th domains

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12
Q

What second messengers are activated by G proteins?!

A

cAMP and phospholipase C

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13
Q

Which receptor has faster effects?!

A

Ion channels

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14
Q

What is integration?!

A

Summation of IPSP’s and EPSP’s

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15
Q

What is temporal integration?!

A

One input

16
Q

What is summation?!

A

More than one input

17
Q

What is caused by higher frequency?!

A

More neurotransmitter is released