Neuropharmacology

Question 1

Na AP invades the terminal and activates

Answer 1

voltage gated calcium channels

Question 2

what do local anaesthetics block?

Answer 2

sodium channels

Question 3

receptor antagonists block the

Answer 3

post synaptic receptor

Question 4

anticholinesterases act to inhibit the breakdown of

Answer 4

ACh

Question 5

what 3 areas of the brain are involved in parkinson’s disease

Answer 5

brain stem

basal ganglia

limbic system and frontal cortex

Question 6

parkinson’s disease is the degeneration of ……. ……… creating a

Answer 6

dopageneric cells

dopamine deficiency in the basal ganglia

Question 7

tyrosine gets converted into DOPA which then gets converted into

Answer 7

dopamine

Question 8

dopaminergic drugs can worsen certain side effects on parkinsons like

Answer 8

nausea

vomiting

pyschosis

impulsivity

Question 9

dopamine ANTAGONISTS improve …….. but worsen …..

Answer 9

the improve the nausea, vomiting etc

they worsen parkinsonism

Question 10

GABA agonists are

Answer 10

anti-epileptic drugs

Question 11

reducing synaptic transmission can be done by

Answer 11

blocking Na or calcium channels

botox

Question 12

increasing synpatic transmission can be done by

Answer 12

potentiate effects of transmitters (GABA agonist)

block transmitter breakdown (anticholinesterases)