neuropathology Flashcards
what can the cells of the CNS be damaged by?
hypoxia trauma metabolic abnormalities nutritional deficiency infection ageing genetics
what cell is the most vulnerable if hypoxia?
neurones
what is the response to axonal injury?
increase RNA and protein synthesis swelling of cell body peripheral displacement for nucleus enlargement of nucleolus break down of myelin sheath
what is the most important histiopathological indicator of CNS injury
gliosis
injury to what cells cause demyelination
oligodendrocytes
what cells line the ventricular system
ependymal cells
if there is is frontal lobe dysfuction what artery is affected?
anterior cerebral artery
where is the most common place for a spontaneous subarachnoid haemorrhage?
circle of willis- berry aneurysm
thunderclap headache
subarachnoid haaemorrhae
most common demyelinating disease
multiple sclerosis
is MS a white or grey matter disease
white
most common type of primary dementia
alzheimers
decrease in brain weigth and size
widening of sulci
narrowing of gyrus
dilation of ventricles
alzheimers
neurofibrillary tangles
alzheimers
progressive dementia with hallucinations and fluctuating levels of attention
lewy body dementia