MS Flashcards

1
Q

describe MS?

A

inflammatory demyelinating disorder of the CNS

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2
Q

who gets MS more- male or female?

A

female

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3
Q

what can you get in MS which causes painful visual loss?

A

optic neuritis

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4
Q

what features of pyramidal dysfunction do you get in MS?

A

increased tone
spasticity
weakness
extensors of upper limb and flexors of lower limbs are weak

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5
Q

what sensory symptoms do you get in MS?

A
pain
paraesthesia-tingling/pins and needles
proprioception- dorsal column loss
numbeness
trigeminal neuralgia
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6
Q

what signs of cerebellar dysfunction do you get in MS?

A
ataxia
intention tremor
nystagmus
past pointing
pendular reflexes
dysdiadokinesis- cant perform rapid altering movements
dysarthria- speech problems
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7
Q

what signs of brain stem dysfunction can you get in MS?

A

diplopia- double vision

facial weakness- facial nerve plasy

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8
Q

signs of internuclear ophthalmoplegia?

A

distortion of binoccular vison
failure of adduction
nystagmus in abducting eye
lag

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9
Q

signs of urinary tract dysfunction?

A
frequency
nocturia
urgency
urge incontinence
retention
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10
Q

is fatigue a big thing in MS?

A

YES YES YES!!

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11
Q

what do they have to have to suggest a diagnosis of MS?

A

at least 2 episodes suggestive of demyelination
dissemination in time and place ( 2 different dates and times)

mcdonald criteria

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12
Q

differential possibilities when you think of MS?

A
vasculitis
granulomatous disorder
vascular disease
infection
metabolic disorder
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13
Q

how do you treat and acute exacerbation of MS?

A

steroids.

may even need to admit for IV steroids

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14
Q

what can you do to improve spasticity?

A

physio
anti -spasmodic agent
oral-baclofen
botox injection

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15
Q

what can you give for sensory symtpoms?

A

anti- convulsant e.g gabepentin

anti-depressant e.g amitryptiline

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16
Q

what can you give for fatigue?

A

amantadine

17
Q

what is first line for disease modifying therapy?

A

Interferon Beta (injectable)

Copaxone (injectable)

Tecfedira (oral agent- first in relapsing and remitting MS)

18
Q

second line therapy ?

A

monoclonal antibody

Fingilomod- oral

19
Q

third line therapy?

A

mitoxantrone- 12 infusions over 2 years

but cardiac toxicity

20
Q

does cannabis help in MS?

A

yes actually

21
Q

describe the inflammatory cascade in MS?

A

immune cells pass through blood-brain barrier

immune cells may reactivate and produce cytokine

immune cells mount autoimmune attack against myeline sheath