muscle and the neuromuscular junction

Question 1

what would this indicate>

weakness
low tone
fasciculations?

Answer 1

lower motor neurone problem

Question 2

most common disorder of neuromuscular junction?

Answer 2

myasthenia gravis

Question 3

autoimmune antibodies to acetyl choline receptors

Answer 3

myasthenia gravis

Question 4

clinical features of myasthenia gravis?

Answer 4

fluctuating weakness- worse through day
extraocular weakness, facial and bulbar weakness

limb weakness- typically proximal

Question 5

how do you treat myasthenia gravis?

Answer 5

pyridostimine ( acetly chlonesterase inhibitor)

thymectomy
immunomodulating
steroids

Question 6

what are fasciculations?

Answer 6

visible fast fine spontaneous twitch

can occur in healthy muscle die to anxiety, caffeine, or stress or fatigue

occurs in denervated msucle which become hyperexcitable

Question 7

what is myotonia?

Answer 7

failure of muscle relaxation after use

Question 8

main symptoms of muscle disease?

Answer 8

myalgia
muscle weakness
wasting
hyporelfexia

Question 9

name some inflammatory disease that effect muscle?

Answer 9

polymyositis and dermatomyositis

Question 10

name some inherited conditions which effect muscle?

Answer 10

muscle dystrophies

myotonic dystrophies

Question 11

name a degenerative disease which affects muscle?

Answer 11

inclusion body myositis

Question 12

what happens in rhabdomyolysis?

Answer 12

damage to muscle causes leakage of large quantities of toxic intracellular contents into plasma

Question 13

myalgia
weakness
myoglobinuria

Answer 13

rhabdomyolysis