Neuropathic Diseases Flashcards
By which pathway do nerves obtain sugar?
Nerves do not require insulin for sugar uptake but instead use the polyol pathway.
The blood sugar difuses across the membrane and is converted to Sorbitol, and then fructose.
Leads to an oxidative effect that destroys the nerves. Sorbitol also has an osmotic effect.
How does capsacin treat neuropathy?
Targets substance P
What causes Beriberi disease?
Thiamine (vit B1) deficiency seen most commonly in alcoholics.
The difference between wet and dry beriberi
Wet beriberi involves the heart.
Dry beriberi is a nervous system disease.
Both related to thiamine deficiency.
Wenicke-korsakoff syndrome is an alcohol related brain damage effecting both language and thinking.
What is the treatment for Beriberi?
100 mg IV thiamine administered immediately.
What is deficient in restless leg syndrom?
Deficiency in vitamin B12, zinc, or folate.
Which bacteria is known to cause guilliane barre syndrome?
Campylobacter jejuni
What antibiotic is known to cause neuropathy?
Metronidazole (flagyl)!!
Which anti lipid medications can cause neuropathy?
Statins can cause neuropathy!!
Which muscles most commonly atrophy in those suffering from charcot marie tooth?
PEroneals and intrinsic musculature of the hands and feet.
Lose the ability to evert the foot and end up in an inverted varus or high arched foot.
Inverted champagne bottle legs?
Pathomnemonic for charcot marie tooth disease.
Which two bacterium most commonly cause meningitis?
H influenza and N. meningitides
What is the trio of tetanus?
Risus Sardonicus
Trismus
Aphagia
How can hypothyroidism cause tarsal tunnel syndrome?
Can lead to lower extremity edema and eventual compression of the tibial nerve under the lacinate ligament.
At what level does the saphenous nerve end?
Ends at the level of the first mptj.
