Neurology - Miscellaneous Flashcards
What is the mechanism of barbiturates
Facilitate GABA-A action by increasing duration of Cl channel opening
What are barbiturates used for
Anxiety
Seizures
Insomnia
What are toxicities to barbiturates
Respiratory and cardiovascular depression
CNS depression
What is the mechanism of benzodiazepines
Facilitate GABA-A action by increasing frequency of Cl channel opening
What are benzodiazepines used for
Anxiety Spasticity Status epilepticus Night terrors and sleepwalking Hypnotic (insomnia)
What are toxicities to benzodiazepines
Dependance
CNS depression with alcohol
What are the mechanisms of opioid analgesics
Opioid agonist
Mu=morphine
Delta=enkephalin
Kappa=dynorphin
What are the IV anesthetics
Barbiturates Benzodiazepines Ketamine Opioids Propofol
What drug is used to treat malignant hyperthermia
Dantrolene
What is the mechanism of L-dopa
Dopamine precursor that can cross the BB
Converted to dopamine in CNS by dopa decarboxylase
What is given with L-dopa and why
Carbidopa
Decarboxylase inhibitor - increases bioavailability of L-dopa in brain
What is L-dopa used for
Parkinsons
What is the mechanism of selegiline
Inhibits MAO-B which metabolizes dopa over NE and 5HT
Increases dopamine
What is selegiline used for
Adjunctive agent to L-dopa in Parkinsons
What is the mechanism of memantine and what is it used for
NMDA receptor antagonist
Alzheimers
