GI - GI Therapy Flashcards
What is the mechanism of -tidine drugs
Reversible block of histamine H2 receptors
Decrease H release by parietal cells
What are the -tidine drugs used for
Peptic ulcer
Gastritis
Mild esophageal reflux
What particular -tidine drug has many toxicities and what are they
Cimetidine
P450 inhibitor, antiadnrogenic, crosses BBB and placenta
What are the -prazole drugs commonly known as
Proton pump inhibitors
What is the mechanism of the -prazole drugs
Irreversibly inhibit H/K ATPase of parietal cells
What are the -prazole drugs used for
Peptic ulcer
Gastritis
Esophageal reflux
Zollinger-Ellison syndrome
What are toxicites to the -prazole drugs
Increase risk of C. difficile infection
Pneumonia
Hip fractures
What is the mechanism of bismuth/sucralfate
Bind to ulcer base allowing HCO3 to reestablish pH
What is the mechanism of misoprostol
PGE1 analog
Increase gastric mucous barrier
What is misoprostol used for
Prevention of NSAID indued ulcers
Who is misoprostol contraindictated in
Pregnant - increases uterine contractions
Side effect of aluminum hydroxide antacid use
Constipation and hypophosphatemia
Proximal muscle weakness, seizures
Side effect of magnesium hydroxide antacid use
Diarrhea, hyporeflexia, hypotension, cardiac arrest
Side effect of ccium carbonate antacid use
Hypercalcemia, rebound acid increase
What is infliximab and what is it used for
TNF-alpha monoclonal antibody
Crohns, ulcerative colitis, rheumatoid arthritis
