Cardio - Lipid Agents Flashcards
What is the mechanism of the -statins
Inhibit conversion of HMG-CoA to mevalonate a cholesterol precursor
What does the -statins have the greatest effect on
Decrease LDL
Slightly increase HDL and decrease TG
What are side effects to the -statins
Hepatotoxicity
Rhabdomyolysis
What is the mechanism of niacin (B3)
Inhibits lipolysis in adipose
Reduces VLDL secretion into circulation
What does niacin (B3) have the greatest effect on
Decrease LDL and increase HDL
Slight decrease TG
What are side effects to niacin (B3)
Red, flushing face reduced by ASA
Hyperglycemia, hyperuricemia
What are the bile acid resins
Cholestyramine
Colestipol
Colesevelam
What is the mechanism of the bile acid resins
Prevent intestinal reabsorption of bile acids
What does the bile acid resins have the greatest effect on
Decrease LDL
Slightly increase HDL and TG
What are side effects to the bile acid resins
Cholesterol stones
What is the mechanism to cholesterol absorption blockers (ezetimibe)
Prevent cholesterol reabsorption at small intestine brush border
What does cholesterol absorption blockers (ezetimibe) have the greatest effect on
Decrease LDL
What are the fibrates
Gemfibrozil
Clofibrate
Benzafibrate
Fenofibrate
What is the mechanism of the fibrates
Upregulate LPL leading to increased TG clearance
What do the fibrates have the greatest effect on
Decrease TG
Slightly decrease LDL and increase HDL
