MSK - Miscellaneous Flashcards
What is the suffix for bisphosphonates
-dronates
What is the mechanism of bisphosphonates
Pyrophosphate analog
Binds hydroxyappetitie and inhibits osteoclast
What are bisphosphonates used for
Osteoporosis
Hypercalcemia
Pagets
What is the mechanism of allopurinol and what is it used for
Inhibit xanthine oxidase
Decreases conversion of xanthine to uric acid
Used in gout
What is the mechanism of febuxostat
Inhibits xanthine oxidase
What is the mechanism of probenecid
Inhibits reabsorption of uric acid in the PCT
What class of drug is etanercept
TNF-alpha inhibitor
What is etanercept used for
Rheumatoid arthritis
Psoriasis
Ankylosing spondylitis
What class of drug is infliximab/adalimumab
TNF-alpha inhibitor
What is infliximab/adalimumab used for
Crohn’s disease
Rheumatoid arthritis
Ankylosing spondylitis
Psoriasis
What is a side effect to TNF-alpha inhibitors
Predispose to infection
Reactivation of TB
