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FA - Pharmacology > Autonomic Drugs - Cholinergics and Anticholinergics > Flashcards

Autonomic Drugs - Cholinergics and Anticholinergics Flashcards

1
Q

What is the mechanism of action of bethanechol

A

Direct cholinergic agonist

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2
Q

What is bethanechol used for

A

Postoperative ileus
Neurogenic ileus
Urinary retention

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3
Q

What is the action of bethanechol

A

Activates bowel and bladder smooth muscle
Resistant to AChE

(Beth needs bethanechol to poop and pee)

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4
Q

What is the mechanism of action of carbachol

A

Direct cholinergic agonist

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5
Q

What is carbachol used for

A

Glaucoma
Pupillary contraction
Relief of intraocular pressure

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6
Q

What is the action of carbachol

A

CARBon copy of AcetylCHOLine (CARBACHOL)

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7
Q

What is the mechanism of action of pilocarpine

A

Direct cholinergic agonist

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8
Q

What is pilocarpine used for

A

Stimulator of sweat, tears, and saliva
Open and closed angle glaucoma

(You cry, drool, and sweat on your PILOw)

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9
Q

What is the action of pilocarpine

A

Contracts ciliary muscle of eye (open angle glaucoma), pupillary sphincter (closed angle glaucoma)
Resistant to AChE

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10
Q

What is the mechanism of action of methacholine

A

Direct cholinergic agonist

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11
Q

What is methacholine used for

A

Challenge test for diagnosis of asthma

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12
Q

What is the action of methacholine

A

Stimulates muscarinic receptors in airway when inhaled

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13
Q

What is the mechanism of action of neostigmine

A

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

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14
Q

What is neostigmine used for

A

Postoperative and neurogenic ileus and urinary retention
Myasthenia gravis
Reversal of NMJ blockade

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15
Q

What is the action of neostigmine

A

Increase endogenous ACh

NEO CNS = no CNS penetration

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16
Q

What is the mechanism of action of pyridostigmine

A

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

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17
Q

What is pyridostigmine used for

A 
Myasthenia gravis (long acting
Does not penetrate CNS
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18
Q

What is the action of pyridostigmine

A

Increase endogenous ACh
Increase strength
pyRIDostiGMine gets RID of Gravis Myasthenia

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19
Q

What is the mechanism of action of edrophonium

A

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

20
Q

What is edrophonium used for

A

Diagnosis of myasthenia gravis (short acting)

21
Q

What is the action of edrophonium

A

Increase endogenous ACh

22
Q

What is the mechanism of action of physostigmine

A

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

23
Q

What is physostigmine used for

A

Anticholinergic toxicity

Crosses BBB to CNS

24
Q

What is the action of physostigmine

A

Increase endogenous ACh

PHYsostigmine PHYxes atropine overdose

25
Q

What is the mechanism of action of donepezil

A

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

26
Q

What is donepezil used for

A

Alzheimers disease

27
Q

What is the action of donepezil

A

Increase endogenous ACh

28
Q

What must you watch for in all cholinomimetic agents

A

Watch for exacerbation of COPD, asthma, and peptic ulcers

29
Q

What is the effect of cholinesterase inhibitor poisoning

A

DUMBBELSS
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, and salivation

30
Q

What is the mechanism of action of benztropine

A

Muscarinic antagonist

31
Q

What organ system does benztropine work on

A

CNS

32
Q

What is benztropine used for

A

PARKinson disease

PARK my BENZ

33
Q

What is the mechanism of action of scopolamine

A

Muscarinic antagonist

34
Q

What organ system does scopolamine work on

A

CNS

35
Q

What is scopolamine used for

A

Motion sickness

36
Q

What is the mechanism of action of ipratropium/tiotropium

A

Muscarinic antagonist

37
Q

What organ system does ipratropium/tiotropium work on

A

Respiratory

38
Q

What is ipratropium/tiotropium used for

A

COPD and asthma

I PRAtropium I can breathe

39
Q

What is the mechanism of action of oxybutynin

A

Muscarinic antagonist

40
Q

What organ system does oxybutynin work on

A

Genitourinary

41
Q

What is oxybutynin used for

A

Reduce urgency in mild cystitis and reduce bladder spasm

42
Q

What is the mechanism of action of glycopyrrolate

A

Muscarinic antagonist

43
Q

What organ system does glycopyrrolate work on

A

Gastrointestinal

Respiratory

44
Q

What is glycopyrrolate used for

A

Parenteral: preoperative use to reduce airway secretions
Oral: drooling, peptic ulcer

45
Q

What is the mechanism of action of atropine

A

Muscarinic antagonist

46
Q

What is atropine used for

A

Treat bradycardia and for opthalmic applications

47
Q

What effects does atropine toxicity have

A

Blocks DUMBBeLSS

Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter

FA - Pharmacology (12 decks)

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