Autonomic Drugs - Cholinergics and Anticholinergics Flashcards by Birju Patel

What is the mechanism of action of bethanechol

Direct cholinergic agonist

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What is bethanechol used for

Postoperative ileus
Neurogenic ileus
Urinary retention

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What is the action of bethanechol

Activates bowel and bladder smooth muscle
Resistant to AChE

(Beth needs bethanechol to poop and pee)

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What is the mechanism of action of carbachol

Direct cholinergic agonist

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What is carbachol used for

Glaucoma
Pupillary contraction
Relief of intraocular pressure

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What is the action of carbachol

CARBon copy of AcetylCHOLine (CARBACHOL)

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What is the mechanism of action of pilocarpine

Direct cholinergic agonist

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What is pilocarpine used for

Stimulator of sweat, tears, and saliva
Open and closed angle glaucoma

(You cry, drool, and sweat on your PILOw)

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What is the action of pilocarpine

Contracts ciliary muscle of eye (open angle glaucoma), pupillary sphincter (closed angle glaucoma)
Resistant to AChE

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What is the mechanism of action of methacholine

Direct cholinergic agonist

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What is methacholine used for

Challenge test for diagnosis of asthma

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What is the action of methacholine

Stimulates muscarinic receptors in airway when inhaled

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What is the mechanism of action of neostigmine

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

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What is neostigmine used for

Postoperative and neurogenic ileus and urinary retention
Myasthenia gravis
Reversal of NMJ blockade

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What is the action of neostigmine

Increase endogenous ACh

NEO CNS = no CNS penetration

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What is the mechanism of action of pyridostigmine

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

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What is pyridostigmine used for

Myasthenia gravis (long acting
Does not penetrate CNS

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What is the action of pyridostigmine

Increase endogenous ACh
Increase strength
pyRIDostiGMine gets RID of Gravis Myasthenia

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What is the mechanism of action of edrophonium

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

What is edrophonium used for

Diagnosis of myasthenia gravis (short acting)

What is the action of edrophonium

Increase endogenous ACh

What is the mechanism of action of physostigmine

Indirect cholinergic agonist

indirectly increase cholinergic stimulation by increasing ACh levels

What is physostigmine used for

Anticholinergic toxicity

Crosses BBB to CNS

What is the action of physostigmine

Increase endogenous ACh

PHYsostigmine PHYxes atropine overdose

What is the mechanism of action of donepezil

Indirect cholinergic agonist | indirectly increase cholinergic stimulation by increasing ACh levels

What is donepezil used for

Alzheimers disease

What is the action of donepezil

Increase endogenous ACh

What must you watch for in all cholinomimetic agents

Watch for exacerbation of COPD, asthma, and peptic ulcers

What is the effect of cholinesterase inhibitor poisoning

DUMBBELSS Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, and salivation

What is the mechanism of action of benztropine

Muscarinic antagonist

What organ system does benztropine work on

CNS

What is benztropine used for

PARKinson disease | PARK my BENZ

What is the mechanism of action of scopolamine

Muscarinic antagonist

What organ system does scopolamine work on

CNS

What is scopolamine used for

Motion sickness

What is the mechanism of action of ipratropium/tiotropium

Muscarinic antagonist

What organ system does ipratropium/tiotropium work on

Respiratory

What is ipratropium/tiotropium used for

COPD and asthma | I PRAtropium I can breathe

What is the mechanism of action of oxybutynin

Muscarinic antagonist

What organ system does oxybutynin work on

Genitourinary

What is oxybutynin used for

Reduce urgency in mild cystitis and reduce bladder spasm

What is the mechanism of action of glycopyrrolate

Muscarinic antagonist

What organ system does glycopyrrolate work on

Gastrointestinal | Respiratory

What is glycopyrrolate used for

Parenteral: preoperative use to reduce airway secretions Oral: drooling, peptic ulcer

What is the mechanism of action of atropine

Muscarinic antagonist

What is atropine used for

Treat bradycardia and for opthalmic applications

What effects does atropine toxicity have

Blocks DUMBBeLSS | Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter