Neuro-oncology Flashcards
glial neoplasm with necrosis and perinecrotic pseudopalisading
glioblastoma
“fried egg” appearance
oligodendrogliomoas
perivascular pseudorosettes
ependymomas
true rosettes
ependymomas
homer-wright roosettes
medulloblastomas
Ki-67
marker of nuclear proliferation
GFAP = glial fibrillary acidic protein
marker of glial intermediate filaments
cytokeratin
marker of epithelial intermediate filaments
CD3
T cells
CD20
B cells
Rosenthal fibers
pilocytic astrocytoma
pleomorphic xanthoastrocytoma
Alexander’s disease
chronic reactive gliosis
Subependymal giant cell astrocytomas
Tuberous sclerosis
Tumors typically presenting w/ seizures
oliogodendrogliomas
gangliogliomas
dysembryoplastic neuroepithelial tumors (DNET)
von hippel-lindau
cerebellar hemangiooblastomas
chromosome 3
Autosomal Dominant
“zellballen” arrangement of nests of cells
paraganglioma
common origin of brain mets
lung > breast > melanoma
paraneoplastic cerebellar degeneration a/w ovarian & breast carcinomas
anti-yo abs
small cell lung carcinoma; a/w sensory neuropathy and neuronopatthy
anti-Hu (ANNA-1) antibodies
opsoclonus myoclonus a/w breast & ovarian cancer
anti-ri (ANNA-2) antibodies
opsoclonus myoclonus in children
Neuroblastoma
paraneoplastic retinal degeeneration, small cell lung cancer
anti-recoverin antibodies
lambert-eaton myasthenic syndrom
ant-voltage gated calcium channel P/Q type abs
limbic encephalitis & testicular germ-cell tumor
anti-ma abs
paraneoplastic encephalitis a/w ovarian teratom
anti-NMDA receptor abs
paraneoplastic stiff person syndrome
anti-amphiphysin
nonparaneoplastic stiff person syndrome
antti-GAD (glutamic acid decarboxylase)
melan-A and HMB-45
positive in melanocytic cells
