Nervous System Flashcards
1
Q
Creatine supplementation is at what dose and frequency
A
5 grams qid
2
Q
Name some side effects of creatine supplementation
A
Gain some water weight and has a dehydrating effect
3
Q
Glycolyosis involves breakdown down glucose into what 2 molecules
A
Lactic acid and Pyruvate
4
Q
Net ATP from 1 glucose molecule, where is the majority of the ATP produced?
A
32 ATP, Electron Transport Chain
5
Q
______ is what it takes to increase the temperature by one degree
A
Calorie
6
Q
What is triglyceride composed of?
A
Glycerole and 3 Fatty Acids
7
Q
How do fat cells get bigger?
A
Increased number of fatty acids present
8
Q
_____ is used when carbohydrates are not available for brain energy while on a Keto diet
A
Acetyle Co Enzyme A
9
Q
What organ combines two molecules of Acetyle Co Enzyme A to make a carbohydrate while on a Keto diet
A
the liver
10
Q
Describe Ketoacidiosis
A
When the liver breaks down fat for fuel, it produces ketones. Ketones are then released leading to an overall increase of ketones in the blood. Has an associated fruity smell
11
Q
What is a ketone
A
2- Acetyle Co Enzyme A
12
Q
Described equilibrium point
A
When the concentration gradient forces equals the electric repulsive force
13
Q
Potassium (K+) is high ______ and ____ outside
A
Inside the membrane, low outside the membrane
14
Q
Sodium (Na+) is _____ on the inside
A
Low
15
Q
Sodium rushes inside the cell is polarization or depolarization
A
Depolarization
16
Q
When you are looking at a gradient with Potassium by itself, and the potassium leaves the cell, what is the electronegativity?
A
-94mV
16
Q
Talking about putting probes to test the electronegativity, where do we put them? Inside or outside the cell
A
Inside the cell always
17
Q
When you are looking at a gradient with Sodium by itself, and the Sodium comes into the cell, what is the electronegativity?
A
+61mV
18
Q
Describe polarization in terms of diffusion potentials
A
Positive on the outside, negative on the inside
19
Q
Describe diffusion potential
A
the potential difference between the inside and outside
20
Q
Why will K+ never reach it’s chemical equilibrium?
A
because at -94mv there is enough charge repulsion to prevent futher movement of K+ to the outside. Negative attraction of the phosphate ions and negatively charged side chains
21
Q
The Nernst Equation is looking at (one or many) types of molecules. Inside or outside the membrane?
A
ONE type, INSIDE
22
Q
What is the Nernst Equation:
A
+/- 61 * log (concentration Inside/ concentration Outside)
23
Q
Nernst Equation: The answer will be _____ if the ion diffusing from the inside to the outside is a negative ion
A
Positive
24
Nernst Equation: __ if the ion diffusing from the inside to the outside is a positive ion
Negative
25
During the Sodium Potassium pump: _____ is pumped to the outside and _____ is to the inside
Sodium -> outside
Inside <- Potassium
26
During the Sodium Potassium pump: ____ Na+ goes to the outside and ____ K+ to the inside
3 and 2, leads a net deficit of + ions on the inside
27
During the Sodium Potassium pump: if the cell is NOT excited the sodium channels are ____
closed
28
During the Sodium Potassium pump: if the cell is NOT excited potassium channels are ____
leaking
29
Why is the cell usually negative on the inside, give 3 reasions:
1. More positive charges on the outside, because Na does not come in but is being pumped out
2. Na is being pumped out much faster than K+ is being pumped in
3. Once K+ is pumped in, it can leak back out
30
What starts the action potential?
Receptor receives stimuli that causes a protein to change shape which allows the sodium in, and that triggers the next channel to open etc etc
31
The Goldman equation is ____ ions (when compared to the Nernst Equation
ALL the ions versus SINGLE ion
32
a nerve action potential starts at ____ mv
-90
33
What does this graph illustrate? What is on the ascending? Descending?
What it takes to stimulate the action potential, need to get from -90mv to 0 in order for the signal to get transported. Depolarization, Repolarization
34
Resting = "_______"
Polarized, -90mv
35
Describe some things that happen during repolarization: Is it fast or slow?
- Fast
- Sodium channels close
- Potassium channels open more than normal-> potassium goes to outside
- the negative "normal" state of the membrane potential is restored
36
What happens when the voltage gated channel is activated?
a protein changed the shape of the activation gate and the channel is opened
37
What happens when the voltage gated channel is closed?
The cell is repolarized back to -90mv
38
What is this picture illustrating?
The impulse will travel in both directions
39
Describe the All-or- None principle.
Once an action potential has been reach, it will travel over the entire membrane
40
The average nerve trunk contains about _____ as many UNmyelinated fibers as myelinated fibers
Twice
41
Describe Saltatory Conduction. Is it slower or faster than traveling across the entire cell membrane?
Where the signal jumps from myelinated fiber node to myelinated fiber node, much faster
42
Saltatory Conduction _____ energy. Why?
Conserves, because only the node depolarizes
43
Label the structure indicated by 1
Node of Ranvier
44
Is myelinated or unmyelinated nerves faster?
Myelinated is faster
45
What are 2 factors that cause sodium ions to diffuse inwards?
Mechanical disturbance
Chemical effects on the membrane
46
How do local anesthetics work?
Calcium in the extracellular fluid stabilizes the membrane which decreases membrane excitability
47
How does Procain and tetracaine work as an anestetic?
Makes it harder for the activation gate of the sodium channel to open, nerve impulses fail to pass along the anesthetized nerves
48
Afferent neuron travel from the ____ to _____
from the periphery to the spinal cord
49
Efferent neuron travels from the _____ to _______
Spinal cord to the effector organ
50
The somasensory map in the brain tells us.....
where the sensation is occurring in the body
51
What happens after the neuron travels to the effector organ?
The organ creates a chemical transmission into the synapse and that chemical substance will act on receptors for some sort of action.
52
The motor neuron is in the _____
gray matter of the spinal cord
53
The axons are _______ gate
voltage
54
Why is the gray matter gray?
The interneurons have very little mylenation so they are gray.
55
Why is the white matter white?
Due to higher levels of mylenation
56
_______ acts on receptor proteins in the membrane of the next neuron
Neurotransmitters
57
All the synapes used for signal transmission in the CNS are _____ synapses
Chemical
58
Where are the majority of presynaptic terminals located?
85% on dendrites, 15% on soma
59
In order for the action potential to proceed the _____ must be more than ______
Excitatory Post Synaptic Potentials (EPSP) more than IPSP -Inhibitory
60
There are more ____ than _____ in the body at any given time.
IPSP than EPSP, (think about glasses resting on your nose, you do not feel unless you focus on them)
61
Second messenger activators are part of the receptor protein called ______
G proteins
62
What component of the G protein is separated from the rest? Describe its function.
Alpha
-opens specific channels
- activates a C-AMP cascade system
- Activates gene transcription
63
*****Excitation can happen in multiple ways. Describe a few.
-Opening of sodium channels (widely used)
- Depress conduction through chloride/potassium channels
- Decrease chloride ions to the inside
-Decrease diffusion of positively charged potassium ions to the outside
- Increase number of excitatory membrane receptors
-Decrease the number of inhibitory receptors
64
Give an example of a type of medication that works on the drug synpases
SSRI
65
Slow acting neurotransmitters are called ______
neuropeptides- they are very small
66
Describe decremental conduction
When the excitatory effects are near the tip of the dendrites but are "leaking" potassium and some of the "electrical current" is lost due to distance
67
temporal sumation
one neuron is firing off faster
68
spacial sumation
bunch of neurons firing off at the same time
69
Name some causes of cell fatigue
70
________ predisposes epileptic seizures. Why?
hyperventilation, pt is breathing out too much CO2
71
______ greatly increased excitability
Alkalosis (High pH)
72
_____ greatly depressed neuronal acitivity
Acidosis
73
Caffeine, theophylline, theobromine and strychinine all ______ neuronal excitablity
increase
74
______ increase neuronal membrane threshold for excitation
Anesthetics
75
Somatic nervous system is _____ and conducts impulses from the _____ to ________
Voluntary, CNS to the skeletal muscles
76
______ nerve endings serve as specialized receptors to detect conscious and subconscious sensory information
Peripheral sensory
77
_____ receptors show sensitivity to body position (temperature, light, sound, smell, taste etc)
Conscious
78
_______ respond to blood gas tension and pH
Chemoreceptors
79
______ react to small changes in arterial blood pressure
baroreceptors
80
________ refers to the sensory receptors that react to mechanical stimuli of touch, pressure, stretch and motion
Mechanoreceptors
81
Describe the pyramidal nerve tracks
Impulses that are shot downwards through the spinal cord through direct routes and interconnected neurons. Nerve excite the alpha motor neurons that control the fine and gross properties of skeletal muscle during intentional movements
82
Why is it called the pyramidal tract?
Because it goes through the medulla oblonga (part/space?) that look like a pyramid, it passes through it that space
83
About 80% of the information received through the pyramidal tract does what? 20% does what?
crosses sides of the brain, stays on the same side of the brain
84
Extrapyramidal tract has how many different pathways? Pyramidal tract?
4
2- Corticospinal and Rubrospinal
85
What is the main difference between pyramidal and extra-pyramidal tracts?
Pyramidal tract has to due with voluntary/thought out muscle movements, Extra-Pyramidal is balance and posture (involuntary)
86
*****Babinski sign manifests as what? What is normal? What does this indicate?
When the bottom of the foot is stroked, the toes are extended in a fanning motion
Toes curl down
Damage to descending upper motor neuron pathway (pyramidal)
87
Name some additional signs of pyramidal tract disorders.
- Babinski sign
- hypertonic spasticity
- Clonus
- hyper-reflexia
- loss of ability to perform fine movements
- muscle wasting from prolonged non-use
88
****Define clonus. Pyramidal or extra-pyramidal?
oscillatory motor response to muscle stretching (Anti-brake locking mechanism)
89
Name some signs of Extra-pyradmial disorders.
- twitching
- resting tremors
- chorea
- myocolonus
-tics
-dystonia
90
Define chorea:
Brief, irregular movements that are not repetitive or rhythmic but appear to flow from one muscle to the next
91
Define myocolonus
continuous flow of involuntary irregular movements. movements are rapid, jerky and explosive in random sequence
92
Define dystonia
related to involuntary and abnormal muscle tension that force patients into awkward and sometimes painful twisted or bent positions
93
Define motor unit
the nerve and all the muscle fibers that it innervates
94
How can you change the amount of force you place on an object?
By changing the number of motor units your body recruits to pick it up.
95
Acetyle Coline is the _____
neurotransmitter
96
What does the cerebellum do in terms of muscle/nerves?
Compares where your body is in space versus where you want the body to be.
Refine movements by recruiting the right number of motor units for the specific task
97
What is the motor pool?
all alpha motor neurons that project to a given muscle collectively
98
What is the size principle?
Within a single motor pool, motor neurons will be recruited in the order of ascending size, smallest first and largest last
99
Name some qualities of small motor neurons
- have the smallest soma membrane surface area
- fewest dendrites and branches
- innervate the fewest muscle fibers
- generate the smallest amount of force
100
White muscle cells in the body equal:
Powerful and fast, but get tired fast, larger cells (according to the size principle)
101
Red muscle cells in the body equals:
fatigue resistance. (marathon runners) Smaller cells (according to the size principle)
102
Red or white motor units get recruited first?
Red first then white
103
What are the two types of mechanoreceptors:
Spindles and Golgi Tendon organs
104
______ detect stretch in the muscle fibers
Spindles
105
______ are the junction of the tendon and skeletal muscle
Golgi Tendon Organs
106
_____ detect tension in the muscle
Golgi Tendon Organs
107
______ sends IPSP to the spinal cord
Golgi tendon organs
108
______ protects the muscle from tearing. How?
Golgi tendon, by sending signals that make the muscle relax
109
The mechanoreptors sends information to the spinal cord or brain? Why is this important?
Spinal cord, because it allows for some refinement of the muscle without the brain aka conscious control
110
What is a muscle spindle?
4 to 6 muscle fibers surrounded by a collageous sheath
111
The size of the collagenous sheath is equal to:
about the size of the EXTRAfusal fibers
112
The fibers inside the sheath are called _____
Intrafusal fibers
113
INTRAfusal fibers are innervated by:
Gama-motor neurons
114
INTRAfusal fibers are surrounded by:
Several sensory axons
115
Extrafusal and Intrafusal fibers are running ______
Parallel
116
______ nuclei are located in the middle of the fiber
Nuclear bag fiber
117
______ nuclei are located across the length of the fiber in a chain like fashion
Nuclear chain fiber
118
_____ Tell EXTRAfusal fibers to contract
Alpha motor neurons
119
Primary spindle afferents are also called ______. These are primary used for ______.
Annulospiral endings, Fast/quick motions
120
***Secondary spindle afferents are also called ______. These are primary used for _____.
Flower- spray endings, posture
121
The stretch of the intrafusal fibers can be caused by two events:
Activation of the gama motor neurons
passively lengthening and shortening the intrafusal fibers
122
What does activating the gama motor neurons mean?
Shortening the distal ends of the intrafusal fibers which stretches the center where the annulospiral sensory nerve endings are
123
Describe some things about the Golgi Tendon Organs
-Within the muscle tendon unit
-Able to detect small changes in force generated within the muscle
- Very sensitive to force
- Sensory info will excite some muscle and inhibit others
