Nerve/Synapse - Lecture 5 Flashcards
3 main types of synapses
- Axodendritic : Synapse on the dendrites
- Axosomatic : Synapse on the soma (cell body)
- Axoaxonic : Synapse on the presynaptic terminal
What structure covers dendrites in a large number
Spines
Within the 3 types of synapses, which one is the most common
Axodendritic synapse
2 types of axodendritic synapse and their distinctions
- Spine synapse - on spines + main EXCITATORY synapse in the brain
- Shaft synpase - on dendrite body (shaft) + INHIBITORY and will equilibrate effect of spine synapse
Something particular about axosomatic synapse
Often inhibitory
How high number of spines on dendrites was visualized
Using antibodies specific to proteins associated to spines and using fluorescence
Even though a neuron has one cell body, it can have ___________ of synpases on its ___________ as its axon seperates in different __________
synapses. presynaptic terminals. branches
Characteristic of AP in neuron’s different branches
Has the same size and pattern/frequency everywhere in a neuron cause it comes from the same cell body
Multiple presynaptic terminals can send a message to the ____________
same postsynaptic spine
2 structures we can recognize in a presynaptic terminal
Presynaptic vesicles and the active zone
What are presynaptic vesicles
spheres of phospholipids containing neurotransmitters
1 structure we can recognize in postsynaptic spine and what is found there
Postsynaptic density. Full of specialized proteins involved in synapse
What is special about active zone
Vesicles are docked there by a complex of proteins
What seperates presynaptic terminal and postsynaptic spine and Structure/Function link
Extremely narrow extracellular space called the synaptic cleft. Extremely narrow to facilitate rapid diffusion of neurotransmitters and maximize synapse speed
2 groups of presynaptic vesicles
Those that are in the active zone and those that are a back up