Blood part 3 Flashcards
3 clinical indices of interest about blood
Number of RBC, amount of Hb and hematocrit
2 diseases associated with abnormal hematocrit and what hematocrit exactly
Ht < 45% (ex. 30%) -> Anemia. Can be caused by fluid retention.
Ht > 45% (ex. 70%) -> Polycythemia. Can be caused by dehydration.
Normal values and polycythemia values for RBC count per volume and Hb concentration
Normal : 5-5.5 x 10^6 RBC / microliter. 16g % Hb
Polycythemia : > 6x10^6 RBC / microliter. >18g % Hb
Relative vs Absolute polycythemia
Relative = Due to lower plasma volume Absolute = Physiological or Pathological
Physiological polycythemia 4 causes
1) High altitudes
2) Increased physical activity
3) Chronic lung disease
4) Heavy smoking
Pathological polycythemia 2 causes
1) Tumours of cells producing erythropoietin (kidney cells)
2) Unregulated production by bone marrow
What is polycythemia vera and values for RBC count per volume and Hematocrit
Blood cancer. Bone marrow does too many RBCs. 7-8 x 10^6 RBC / microliter. Ht approx. 70%
Problem with polycythemia
High blood viscosity -> sluggish blood flow and more risks of blood cloting
Anemia definition
Decrease in oxygen-carrying capacity of blood
F and M w/ Anemia -> RBC count and Hb content
M : 4x10^6 RBC/microliter and <11 g% Hb
F : 3.2 x 10^6 RBC/microliter and <9g %
Classifications of morphologic anemias
1) Microcytic (<80 u^3), Normocytic (80-94 u^3), Macrocytic (>94 u^3) (about volume so microcytic smaller diameter and macrocytic bigger diameter.
2) Normochromic (=33%) Hypochromic (<33%) (about % of RBC volume occupied by Hb)
On microscope, how to distinguish different morphologic anemias
Microcytic, normocytic and macrocytic -> sizes of RBCs
Normochromic or hypochromic -> colour of RBCs
3 etiologic anemias
1) Diminished (RBC) production 2) Increased (RBC) destruction 3) Ineffective (RBC) maturation
3 causes for diminished production of RBC (first etiologic anemia)
1) Abnormal site 2) Abnormal stimulus 3) Inadequate raw materials
Which anemia associated with diminished production of RBC due to abnormal site + causes (3) + morphologic classification
Aplastic (hypoplastic) anemia. a. uknown cause b. exposure to radiation c. chemicals or drugs.
Morph. class. of anemia : normocytic, normochromic
What causes anemia associated with diminished production due to abnormal stimulus + morphologic classification
Stimulation failure -> renal disease (EPO produced by kidneys)
Morph. class. of anemia : normocytic, normochromic
Which anemia associated with diminished production of RBC due to inadequate raw materials + causes (2) + morphologic classification
Iron deficiency anemia.
a. High requirements (infancy, adolescence, pregnancy)
b. Inadequate supplies due to 1) Failure to absorb Fe (gastrointestinal tract defficiency) 2) Dietary defficiency 3) Loss of Fe in hemorrhage (hemorrhage = loss of RBC + loss of Fe)
Morph. class. of anemia : microcytic, hypochromic
Total amount of iron in body and its % distribution
4g. 65% Hb. 30% stored. 5% myoglobin (muscle cells). 1% enzymes
Daily intake of iron and daily absorption from gut for M + F and what it depends on
15-20 mg daily. Gut absorbs 1 mg daily for males and 2 mg daily for females (depending on need).
Erythropoiesis iron requirement daily
25 mg
Iron that comes from RBC destruction and what happens with it
25 mg (24 mg recycled, 1 mg lost -sweat)
How much iron in 1 g of Hb
3.5 mg
Why women require 2 mg Fe daily
15g Hb/100 mL = 50 mg Fe (because 15 g * 3.5 mg Fe/1 g Hb)
Menstrual loss : 50 mL of blood so 25 mg Fe
25 mg + 28 mg (1 mg lost daily) = 50 mg/month = 2 mg daily
Second anemia type/etiology and names
Ineffective maturation. Maturation failure anemia
Cause of maturation failure anemia and morph. classification
Deficiencies in Vitamin B12 and folic acid (required for normal synthesis of DNA). Macrocytic RBCs, normochromic RBCs
What can cause lack of vitamin B12
Failure to absorb it
What can cause lack of folic acid
Dietary absence, overcooking vegetables
Vitamin B12 absorption mechanism
Vitamin B12 goes in digestive system. Joins intrinsic factor secreted by stomac cells in the stomac to form IF-B12 complex. IF-B12 complex absorbed in ileum by a receptor.
What can cause a failure to absorb B12 and what pathology would occur
Intrinsic Factor deficiency or ileum disease -> Pernicious anemia
Anemia type/etiology other than increased RBC destruction. different names and what may come with it
Survival disorders/Hemolytic anemias - may be accompanied by jaundice
Survival disorders/Hemolytic anemias etiology (2)
1) Congenital
2) Acquired
Congenital survival disorders causes (3)
1) Abnormal membrane structure (less flexible, more fragile) ex. hereditary spherocytosis (spherical RBCs)
2) Abnormal enzyme systems (abnormal metabolism)
3) Abnormal hemoglobin structure ex. sickle cell anemia (half moon shape) ex. Thalassemia - deficient synthesis of globin amino acid chains
Acquired hemolytic anemia causes (3)
Toxins, drugs, antibodies. Kill RBCs
Name for blood loss. 2 types and name of accumulation of blood in tissues
Hemorrhage. External and internal (into tissues). Hematoma = acccum. of blood in tissues
Hemostasis def.
Arrest of bleeding following vascular injury
3 overlaping mechanisms in hemostasis and which part of hemostasis they’re involved in
Vascular response. Platelet response. Clot formation. Vascular resp. and Plat. response = primary hemostasis. Platelet resp. and clot formation = secondary hemostasis
Time for primary hemostasis to occur
couple seconds after injury