Neoplasms Flashcards
Hamartoma
Malformation that presents a mass of disorganized tissue indegenous to the particular site
NON NEOPLASTIC
Horistoma
Congenital anomaly (heterotopic rests)
Malignant neoplasm with oma
Lymphoma
Mesothelioma
Melanoma
Seminoma
Villous adenoma of the colon may undergo malignant transformation in how many % ?
In 50% of cases
Dysplasia
= intraepithelial neoplasia
Architectural disarrangement
Cells are abnormally large, pleomorphic with hyperchromatic nuclei
More abundant mitotic figures
High grade dysplasia
Carcinoma in situ : when dysplastic changes are marked and involve the entire tickness of epithelium
A desmoplastic reaction
Scirrhous carcinoma
Indian files arrangement is seen in
Scirrhous desmoplastic carcinoma
It arise in pancreas stomach and breast
Familial basal cell carcinoma syndrome
Gorlin syndrome
Inherited defect in PTCH gene
An example of a neoplasm localy malignant
Basal cell carcinoma
Leiomyoma
Beningn neoplasm derived from smooth muscle
Arises in body of uterus
Uterine leiomyomas are also known as :
Myomas and fibroids
Which leiomyomas may be pedunculated and undergo torsion with hemorrhagic necrosis
Subserosal and submucosal
The most important symptoms are produced by which type of leiomyomas ?
Submucosal leiomyomas
Most common soft tissue tumor of adult ?
Lipoma
Most common subtype of lipoma
Conventional lipoma -> well encapsulated soft yellowish mass
Most common malignant neoplasm of the bone
Osteosarcoma : malignant mesenchymal tumor in which cells produce bone matrix
Bimodal age distribution 2 peaks :
75% occur in patients younger than age 20
Smaller second peak occurs in elderly who suffer from other disease : paget disease, prior irradition, bone infarct
Sites of osteosarcoma
60% in knee
Men are more affected the. Women (1,6 :1)
Osteosarcoma genetic abnormalities
RB, TP53, CDKN2A(p16,p14) MDM2, CDK4
Ewing sarcoma
85% trans (11;22)
Presence of Homer-Wright rosettes
Ewing sarcoma
Multiple myeloma clinical course
CRAB CALCIUM RENAL FAILURE ANEMIA BONE LESIONS
Bence-Jones protein
Light chains of immunoglobulins found in urine
Most common soft tissue sarcoma of childhood
Rhabdomyosarcoma (skeletal muscle tumor)
Rhabdomyoblasts are known as tadpole or strap cells
