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Patho > Neoplasms > Flashcards

Neoplasms Flashcards

1
Q

Hamartoma

A

Malformation that presents a mass of disorganized tissue indegenous to the particular site

NON NEOPLASTIC

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2
Q

Horistoma

A

Congenital anomaly (heterotopic rests)

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3
Q

Malignant neoplasm with oma

A

Lymphoma
Mesothelioma
Melanoma
Seminoma

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4
Q

Villous adenoma of the colon may undergo malignant transformation in how many % ?

A

In 50% of cases

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5
Q

Dysplasia

A

= intraepithelial neoplasia
Architectural disarrangement
Cells are abnormally large, pleomorphic with hyperchromatic nuclei

More abundant mitotic figures

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6
Q

High grade dysplasia

A

Carcinoma in situ : when dysplastic changes are marked and involve the entire tickness of epithelium

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7
Q

A desmoplastic reaction

A

Scirrhous carcinoma

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8
Q

Indian files arrangement is seen in

A

Scirrhous desmoplastic carcinoma

It arise in pancreas stomach and breast

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9
Q

Familial basal cell carcinoma syndrome

A

Gorlin syndrome

Inherited defect in PTCH gene

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10
Q

An example of a neoplasm localy malignant

A

Basal cell carcinoma

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11
Q

Leiomyoma

A

Beningn neoplasm derived from smooth muscle

Arises in body of uterus

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12
Q

Uterine leiomyomas are also known as :

A

Myomas and fibroids

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13
Q

Which leiomyomas may be pedunculated and undergo torsion with hemorrhagic necrosis

A

Subserosal and submucosal

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14
Q

The most important symptoms are produced by which type of leiomyomas ?

A

Submucosal leiomyomas

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15
Q

Most common soft tissue tumor of adult ?

A

Lipoma

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16
Q

Most common subtype of lipoma

A

Conventional lipoma -> well encapsulated soft yellowish mass

17
Q

Most common malignant neoplasm of the bone

A

Osteosarcoma : malignant mesenchymal tumor in which cells produce bone matrix

Bimodal age distribution 2 peaks :
75% occur in patients younger than age 20

Smaller second peak occurs in elderly who suffer from other disease : paget disease, prior irradition, bone infarct

18
Q

Sites of osteosarcoma

A

60% in knee

Men are more affected the. Women (1,6 :1)

19
Q

Osteosarcoma genetic abnormalities

A

RB, TP53, CDKN2A(p16,p14) MDM2, CDK4

20
Q

Ewing sarcoma

A

85% trans (11;22)

21
Q

Presence of Homer-Wright rosettes

A

Ewing sarcoma

22
Q

Multiple myeloma clinical course

A 
CRAB 
CALCIUM 
RENAL FAILURE 
ANEMIA 
BONE LESIONS
23
Q

Bence-Jones protein

A

Light chains of immunoglobulins found in urine

24
Q

Most common soft tissue sarcoma of childhood

A

Rhabdomyosarcoma (skeletal muscle tumor)

Rhabdomyoblasts are known as tadpole or strap cells

Patho (14 decks)

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