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Patho > Intro Patho > Flashcards

Intro Patho Flashcards

1
Q

Mallory bodies
Def
Location

A

Intracellular protein accumulation
Hyaline degenaration
Aggregated intermediate filaments in hepatocytes

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2
Q

Extracellular protein degeneration (accumulation)

A

Collagen degeneration

Amyloidosis

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3
Q

World thrombosis day

A

Oct 13

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4
Q

Virchow’s node

A

The presence of metastatic cancer in a lymph node in left supraclavicular fossa

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5
Q

Virchows method of autopsy

A

Each organ is taken out one by one

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6
Q

Most common type of systemic amyloidois

A

AL amyloidosis

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7
Q

Glomerular amyloidosis results in

A

Proteinuria

Nephrotic syndrome

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8
Q

Treatment of AA amyloidosis

A

Inixomab monoclonal antibody against tumor necrosis alpha

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9
Q

Calcium degeneration (accumulation) causes

A

Hyperparthyroidism
Overdosage of Vit D
Destruction of bine
Alkalosis

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10
Q

Pathognomic for gout

A

Tophi : deposit of uric acid crystals (monosodium urate crystals)

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11
Q

Gout : crystal deposition disease type I results in (3)

A

Painful attacks of gout
Urate nephropathy
Tophi formation

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12
Q

Secondary gout causes

A 
Leukemia or polycythemia 
Some lymphomas (neoplasm produce large number of cell nuclei)
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13
Q

Symptoms of podagra (arthritis at the joint of the large toe)

A

Very painful
Lasts a week
Self limiting

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14
Q

Gout patho : urate crystals lead to activation of

A

NLRP3 inflammasome (cryopyrin) -> activation of caspase -> release of cytokines IL 1, 18, 8 and TNF -> attraction of neutrophilic granulocytes

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15
Q

Sheehan’s syndrome

A

Acute pospartum pituitary necrosis ->caused by blood loss and or hypovolemic shock during delivery

 hypocortism 
Hypothyroidism 
Hypogonadism 
Loss of growth hormone 
Prolactin production
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16
Q

Sheehan syndrome symptoms

A 
Weakness 
Dryness and wrinkling of the skin 
Premature ageing 
Hypotension 
Cold intolerance 
Constipation 
Pallor anemia 
Bradycardia 
Hypoglycemia 
Insulin hypersensitivitt
17
Q

Exemple of Hyperactivity

A

Exhaustion of isletic beta cells in acquired diabetes

18
Q

Autoimmunization exemple

A

Chronic thyroiditis (Hashimoto)

Most common cause of hypothyroidism in USA
Formation of CD8+ cytotoxic T cells distroying parenchyma

19
Q

Name of oxyphillic metaplasia of follicular cells

A

Hurthle
Askenay cells
Oncocytes

20
Q

Liver brown atrophy

A

Lipofuscin in hepatocytes

21
Q

Monckeberg calcification

A

Calcium deposits are found in the muscular middle layer of the wall of arteries (tunica media)

22
Q

Granulomatosis with polyangiitis

Known as Wegeners granulomatosis

A

Is a form of vasculitis that affect small and medium vessels in many organs but mostly upper respiratory tract and the kidneys

> 90% test positive for ANCA but it is not conclusive

Necrotizing granulomas are hallmark of the disease

Patho (14 decks)

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