Mechanism Of Cell Injury

Question 1

An example of fibrinoid necrosis

Answer 1

Complexes of antigens and antibodies are deposited in cell wall arteries

Eg polyarteritis nodosa

Question 2

Russel bodies

Answer 2

Newly synthesised immunoglobulins that may occur in the RER of some plasma cells forming rounded eosinophilic Russel bodies

Question 3

Difference between distrophic and metaplastic calcification

Answer 3

Dystrophic cal : deposition occurs in dead or dying tissues, occurs in normal calcium levels

Metaplastic cal: deposit in normal tissue secondary to hypercalcemia

Question 4

Diseases caused by misfolding of proteins

Answer 4

Cystic fibrosis / CFTR/ defects in chloride transports

Familial hypercholeterolemia / loss of LDL receptor

Tay Sachs disease / hexosaminidase B subunit / lack of the lysosomal enzyme leads to storage of GM2 gangliosides in neurons

Alpha 1 antitrypsin def/ alpha1 antitrypsin

Creutzfeld Jacob disease / prions / abnormal folding PrP causes neuronal cell death

Alzeimer disease/ Abeta peptide / abnormal folding of Abeta peptide causes aggregation within neurons and apoptosis