Gastro

Question 1

Most common site of gastric cancer is

Answer 1

Pyloric area (50%)
2- lesser curvature (25%)
3- Cardia and body
4- LEAST Greater curvature (3-5%)

Question 2

Incidence of gastric cancer has diclined in which type ?

Answer 2

Distal stomach and intestinal type

Question 3

Proximal cancers in stomach have :

Declined or arised ?

Answer 3

Arised (related to barrett esophagus and GERD?)

Question 4

Complication of GERD

Answer 4

Barrets esophagus
Squamous cell epithelium -> gastric type glandular epi with intestinal metaplasia

Ulceratiin with stricture formation

Glandular dysplasia with risk for adenomacarcinoma

Question 5

The most common malignancy of the stomach

Answer 5

Gastric adenocarcinoma 90%
Symptoms : dyspepsia
Dysphagia
Nausea

Question 6

EBV-positive gastric tumors occurs in

Answer 6

Proximal stomach and most commonly have a diffuse morphology with a marked lymphocytic infiltrate

Question 7

Prognostic indicators for gastric cancer

Answer 7

Depth of invasion and extent of nodal and distant metastasis at time of diagnostic

Question 8

5-year survival rate for advanced gastric cancer

Answer 8

Below 20%

Question 9

5% of all gastric malignancies are

Answer 9

Primary lymphomas ->1- most common is indolent extranodal marginal zone B cell lymphomas = lymphomas = MALTomas

2nd most common : diffuse large B cell lymphoma

Question 10

Gastric Carcinoid may be associated with

Answer 10

Endocrine cell hyperplasia
Chronic atrophic gastritis
Zollinger-Ellison syndrome

(They grow slower than carcinoma)

Low or intermediate grade neuroendocrine tumors

Question 11

High grade neuroendocrine tumors = neuroendocrine carcinoma

Answer 11

Display necrosis and are found in Jejunum

Question 12

Hirschsprung disease

Answer 12

1/5000
Congenital defect in innervation of colon (defective neural crest cell migration from cecum to rectum-> functional obstruction)
Heterozygous loss of function mutations in the receptor tyrosine kinase RET account for majority of familial cases and 15% of sporadic cases
More common in male
But more severe in female

Question 13

Abetalipoproteinemia

Answer 13

Mutation in microsomal triglyceride transfer proteins and free fatty acids

Question 14

Dermatitis Herpetiformis

Answer 14

10% on children suffering from Celiac disease

Question 15

Kayser-Fleischer rings

Answer 15

Sign of Wilson disease
Dark ring that encircle iris
Due to copper depo in part of the cornea

Question 16

Wilson disease

Answer 16

Low blood ceruloplasmin level
Neurological symptoms
And KF rings

Question 17

Mittelschmerz

Answer 17

Pain associated with ovulation

Question 18

Most common tumor of the appendix is

Answer 18

Carcinoid

Question 19

Pseudomyxoma peritonei

Answer 19

Fatal

Semisolid mucin

Question 20

Cushing ulcer

Answer 20

Gastric ulcer associated with intracranial pressure

Also called Rokitansky-Cushing syndrome