Liver Pancreas Gallbladder

Question 1

Asymptomatic acute infection

Answer 1

Serologic evidence only

Question 2

Chronic hepatitis

Answer 2

Without of with progression to cirrhosis

Question 3

Chronic carrier state

Answer 3

Asymptomatic without apparent disease

Question 4

Fulminant hepatitis

Answer 4

Subamassive to massive hepatic necrosis with acute liver failure

Question 5

Histological picture of acute viral hep

Answer 5

Hypercellularity and disarrangement of liver structure

Inflammatory infiltrate (mostly lymphocytes) in portal tracts

Question 6

Histo picture in acute viral hep Damage of hepatocytes
Increase in number of Kuppfer cells

An inconstant finding is cholestasis

Answer 6

Vacuolar ballooning degeneration
Hepatocytes in apoptosis- apoptotic Councilman bodies
Colliquative=Liquefactive necrosis
In severe cases bridging necrosis

Question 7

Indication for HBV

Answer 7

Ground-glass hepatocytes- accumulation of HBsAg (chronic hep)

Question 8

Indication for HCV

Answer 8

Steatosis/fatty change of hepatocytes (acute and chronic hepatitis)

Ductular proliferation in portal tract and lymphoid aggregate formation (chronic hep)

Question 9

Most common extra hepatic biliary tract malignancy

Answer 9

Gallbladder carcinoma

More common in women
Seventh decade
More frequent in Mexico and Chili

Important risk factor : gallstones which are present in 60-95%
However only 0.5% of pat with gallstones dev gallbladder cancer

Prognosis : really bad, 5y 5%

Question 10

Most carcinoma of the gallbladder are :

Answer 10

Adenocarcinoma
5% are squamous cell carcinomas
Minority are neuroendocrine tumors