Neoplasm Flashcards
Hypoplasia
Incomplete or underdevelopment of an organ with decreased number of cells
Organ fail to reach normal size
Di george syndrome
Thymic hypoplasia causing T cell deficiency
Aplasia
Absence of an organ due to primordium failure , organ could just be a fibrous cord
Agenesis
Complete absence of an organ and it’s primordium
Is Corpus callosum agenesis compatible with life ?
Yes , but chil may be mentally retarded with normal mental function
Is Kidney agenesis compatible with life ?
Not when bilateral. Compatible when unilateral
What happens to normal kidney when there unilateral kidney agenesis
The normal kidney hypertrophies and chronically fails (CRF)
Harmatoma
Excessive and focal growth of cell forming mass of mature and specialized cells indigenous to site of mass
Is harmatoma benign or malignant
Benign
Ectopia
Congenital displacement of any organs or tissues
Ectopia Cordis
Absence of sternum and pericardium causing heart to be exposed
Ectopia lentis
Lens up outward displacement in Marfans syndrome
Choristoma/ heterotopia
Ectopic collection of normal tissue
Dysplasia
Disordered cells with reversible proliferation , loss of uniformity in respect to size, shape and orientation
Neoplasia
Persistent abnormal growth of tissue forming neoplasm
Purposeless and autonomic mass
Classification of tumors
Histogenetic (epithelial or connective tissue origin)
Behavioural (benign and malignant)
Histological (anaplastic, follicular, papillary)
Naked eye appearance - ( annular, fungating, schirrous, medullary)
Functional- insulinoma, glucagonoma
Aetiological- radiation, chemical, carcinogen, microbial
Main classification of neoplasm
Histogenesis
Behavior
Benign neoplasm
Neoplasm with good prognosis
do not spread , do not invade , and generally do not kill
Malignant neoplasm
Neoplasm with bad prognosis
Can spread and kill
Secondary malignant tumor
Metastatic tumor from another site
Primary malignant tumor
Tumor from original site
Basic component of tumor cells
Parenchyma - can proliferate
Supporting connective tissue - helps in tumor growth and contain blood vessels
Messenchymal benign tumor
Lipoma Fibrous Chondrome Osteoma Leiomyoma Rhabdomyoma
Epithelial benign tumor types
Adenomas- glandular cells origin
Papillomas- surface epithelium origin with fingerlike or warty projections
Cystadenomas
Large cysts benign tumors
Follicular adenomas
Form follicles benign tumors
Papillary cystadenoma
Fingerlike projection in epithelium of cyst - benign tumor
Suffix for malignant tumor of mesenchyme
Sarcoma
Suffix for malignant cancer of the epithelium
Carcinoma
Mixed tumors
Tumors arising from multiple cells types
Example of mixed tumors
Salivary glands tumors
Fibroadenoma of breast
Teratomas
Cancer cells that arise from totipotent cells
Can be malignant or benign
Eponymous cancers example
Burkitt lymphoma
Wills tumors
Hodgkin’s disease
Krukenberg tumor
Cancer
Any malignant neoplasm
Benign tumor of adipose tissue
Lipoma
Benign tumor of fibrous tissue
Fibroma
Benign tumor of bone
Ostéoma
Benign tumor of cartilage
Chondroma
Benign tumor of smooth muscle
Leiomyoma
Benign tumor of skeletal muscle
Rhabdomyoma
Benign tumor of blood vessel
Hemangioma
Malignant tumor of adipose cells
Liposarcoma
Malignant tumor of fibrous tissue
Fibrosarcoma
Malignant tumor of bone
Osteosarcoma
Malignant tumor of cartilage
Chondrosarcoma
Malignant tumor of smooth muscle
Leiomyosarcoma
Malignant tumor of skeletal muscle
Rhabdomyosarcoma
Malignant tumor of blood vessel
Angiosarcoma
Malignant tumor of nerve
Malignant schwanomma
Malignant tumor of squamous cellsl
Squamous cell carcinoma
Malignant tumor of transitional cell
Transitional cell carcinoma
Malignant tumor of placenta
Choriocarcinoma
Benign tumor of nerve cell
Neurofibromas
Benign tumor of squamous cells
Squamous cell papilloma
Benign tumor of transitional cell
Transitional cell papilloma
Benign tumor of placenta
Hydatidiform mole
Benign tumor of breast nodule
Fibroadenoma
Benign tumor of salivary glands
Pleiomorphic adenoma
Benign tumor of melanocytes
Melanocytic nevus
Malignant tumor of breast lobule
Ductal or lobular carcinoma
Malignant tumor salivary glands
Malignant mixed tumors
Malignant tumor of melanocytes
Melanoma
Malignant tumor of hematopoietic cells ( always malignant)
Leukaemia
Malignant tumor of lymphoid tissue ( always malignant)
Lymphoma
Benign tumor growth rate
Slow
Malignant tumor growth rate
relatively rapid
Benign tumor mototic activity
Low
Malignant tumor mitotic activity
High
Benign tumor histological resemblance to normal tissue
Good
Malignant tumor histological resemblance to normal tissue
Variable often poor
Benign tumor nuclear morphology
Often normal
Malignant tumor nuclear morphology
Usually hyper chromatic, irregular outline , multiple nucleoli and pleomorphic
Benign tumor invasion?
Non
Malignant tumor invasion ?
Yes