Atrophy Flashcards
1
Q
Atrophy definition
A
Decrease in cell size
2
Q
Cause of cell atrophy
A
Decreased demand to organ leading to less proteins, mitochondria, ER
3
Q
Physiological atrophy reasons
A
Embryonic structure not used
Physiological cycles like in endometrium
4
Q
Pathological reasons of atrophy
A
Decreased workload Loss of innervation Decreased blood supply Decreased Aging Radiation Pressure Inadequate nutrition
5
Q
Organ morphology in atrophy
A
Small size
Brown color due to lipofuscin
6
Q
Mechanism of atrophy
A
Autophagy=> decrease number of intracellular component
Apoptosis
7
Q
Autophagy 1 st pathway explained
A
Membrane vacuoles bind organelle
Lysosomes discharge content and debris formed under the form of lipofuscin
8
Q
Autophagy 2 nd pathway
A
Proteosomal dAmage of organelles with ubiquitin
9
Q
Mechanism of atrophy
A
Decreased protein synthesis
