Neoplasia

Question 1

slow growing, encapsulated mass of orderly cells, no invasion

Answer 1

benign tumor

Question 2

fast growing, invasive mass of disorderly cells, not encapsulated

Answer 2

malignant tumor

Question 3

tumor is large and localized

Answer 3

primary malignancy

Question 4

tumor is small and multifocal

Answer 4

metastatic malignancy

Question 5

genetic mutation linked with some cancers

Answer 5

oncogene

Question 6

gene which governs the growth of normal tissue

Answer 6

proto-oncogene

Question 7

chemicals, radiation, or germs that may cause cancer

Answer 7

carcinogens

Question 8

agents capable of causing genetic material; may cause cancer

Answer 8

mutagens

Question 9

change in one base; neurofibromatosis, adenomatous polyposis coli

Answer 9

DNA point mutation

Question 10

gene segments are exchanged; Burkitt’s lymphoma, leukemia

Answer 10

translocation

Question 11

gene segment is duplicated; N-myc is neuroblastoma

Answer 11

amplification

Question 12

gene which prevents normal cells from becoming malignant

Answer 12

cancer suppressor gene

Question 13

inactivation of cancer suppressor genes; BRCA in breast cancer

Answer 13

anti-oncogenes

Question 14

Starry-sky appearance on histo; HHV type 4 ARBO virus

Answer 14

Burkitt’s lymphoma

Question 15

Binucleated cells; associated with Hodgkin’s lymphoma

Answer 15

Reed Sternberg cells

Question 16

ARBO virus linked with Burkitt’s lymphoma

Answer 16

Epstein-Barr virus

Question 17

Linked with hepatocellular carcinoma

Answer 17

Hepatitis C

Question 18

Malignant plasma cells, Bence Jones protein, recurrent infections

Answer 18

multiple myeloma

Question 19

benign smooth muscle tumor in the uterus

Answer 19

uterine leiomyoma

Question 20

Blood malignancy with numerous immature WBC’s

Answer 20

leukemia

Question 21

leukemia m/c in young children

Answer 21

acute lymphocytic leukemia

Question 22

leukemia associated with Auer rods in adults

Answer 22

acute myelogenous leukemia

Question 23

leukemia associated with the Philadelphia chromosome

Answer 23

chronic myelogenous leukemia

Question 24

translocation involving chromosome 9 and 22

Answer 24

Philadelphia chromosome

Question 25

leukemia m/c in 60+ patients; asymptomatic

Answer 25

chronic lymphocytic leukemia

Question 26

linked with nitrosamine and alcohol use; squamous cell type

Answer 26

esophageal cancer

Question 27

linked with exposure to asbestos; malignancy of the pleura

Answer 27

mesothelioma

Question 28

linked with exposure to benzene

Answer 28

Leukemia

Question 29

linked with exposure to aflatoxin for moldy groundnuts or corn

Answer 29

hepatocellular carcinoma

Question 30

linked with exposure to uranium and smoking

Answer 30

lung cancer

Question 31

linked with exposure to Epstein-Barr virus

Answer 31

Burkitt’s lymphoma

Question 32

caused by HPV type 16 and 18, most common gynecological cancer

Answer 32

cervical cancer

Question 33

caused by HHV type 8 in AIDS patients

Answer 33

Kaposi sarcoma

Question 34

m/c site for malignant tumors to spread

Answer 34

lung cancer

Question 35

tumor marker for choriocarcinoma and seminoma

Answer 35

Beta-HCG

Question 36

tumor marker for colon cancer

Answer 36

carcinoembryonic antigen

Question 37

tumor marker for prostate cancer

Answer 37

PSA

Question 38

tumor marker for ovarian cancer

Answer 38

CA-125

Question 39

tumor marker for breast cancer

Answer 39

BRCA-1 and 2

Question 40

tumor maker for hepatocellular carcinoma

Answer 40

alpha fetoprotein

Question 41

BCR-alb tumor marker

Answer 41

chronic myelogenous leukemia

Question 42

p16 tumor marker

Answer 42

malignant melanoma

Question 43

m/c cancer in males

Answer 43

prostate

Question 44

m/c cancer in females

Answer 44

breast

Question 45

second m/c cancer and number 1 in death

Answer 45

lung

Question 46

10% are malignant, bilateral, run in families, VMA excreted in urine

Answer 46

pheochromocytoma