Neoplasia

Question 1

Lipomas

Answer 1

Common, benign tumors that arise from the subcutaneous fat and present as soft, mobile masses that are stable or enlarge slowly over time

Biopsy shows well-differentiated mature adipocytes with a fibrous capsule

Question 2

Liposarcomas

Answer 2

Malignant tumors that originate from adipose tissue

Question 3

Adenocarcinomas

Answer 3

Originate from glandular epithelium and consist of a disorganized mass of malignant cells that form glandular structures that may stain positive for mucin

Question 4

Where is keratin production seen in metastatic disease?

Answer 4

Squamous cell carcinomas - aris in organs that are normally lined by stratified squamous epithelium

Question 5

Anaplasia

Answer 5

An extreme degree of peomorphism - usually associated with aggresive malignant tumors

Undifferentiated (anaplastic) thyroid cells lose their ability to produce thyroglobulin, so a stain for thyroglobulin would be negative.

Histology of anaplasia may show undifferentiated cells with abnormal mitoses and possibly giant
cells.

Question 6

Carcinoma in situ is characterized by what?

Answer 6

Irreversible nuclear changes and lack of invasion

Question 7

E-cadherin in metastatic processes

Answer 7

Plays an important role in cellular adhesion

Acts to oppose metastatic processes