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Neoplasia Flashcards

1
Q

Dx agente citotoxico alquilante

A

Mecloretamina
Ciclofosfomida
Isofosfomida
Melfan
Clorambucilo

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2
Q

Fx se uso 1ra guerra mundial

A

Mecloretamida

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3
Q

Semivida mecloretamida

A

Corta

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4
Q

Uso mecloretamida

A

Linfoma hodking

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5
Q

Adm mecloretamida

A

Iv

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6
Q

Toxicidad mecloretamida

A

Hematog

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7
Q

Fx más usado alquilante

A

Ciflofosfomida
Clorambucilo

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8
Q

Adm alquilante iv y vo

A

Ciclofosfomida
Clorambucilo

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9
Q

Adm solo vo de alquilante

A

Isofosdomida
lomustina

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10
Q

Adm solo iv alquilante

A

Mecloretamina

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11
Q

Ciclofosfomida
Adm
E
Dist

A

V.o iv
Orina
Amplia

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12
Q

Clicofosfomida toxic

A

Alopecia mielosupresiok emesis

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13
Q

Ciclofosfomida uso

A

Mamá
Ovario
Leucemia
Linfomas ambos

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14
Q

Isofosfomida uso

A

Sarcoma
vejiga
pulmonar
cuello uterino

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15
Q

Interfiere síntesis adn alquilante

A

Melfan

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16
Q

Toxic porque actúa en cell sanas alquilante
Que cell?
Que fx

A

Melfan
Sangre y digestivo

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17
Q

Uso melfan

A

Melanoma, hueso, tejido blando y ovario

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18
Q

Toxic
Clorabucilo

A

Mielosuprwcion alopecia y emesis

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19
Q

Diferencia uso de ciclofosfomida y Clorambucilo

A

Ciclofosfomida ambos linfomas
Clorambucilo solo no Hodking

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20
Q

Alquilante nitrosourea

A

Lambustina

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21
Q

Alquilante inestable en solución acuosa

A

Mecloretamina

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22
Q

Solubilidad lomustina

A

Alta

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23
Q

Alquilante con el nivel plasmatico más bajo y cuanto es

A

30%
Lombustina

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24
Q

Uso lomustina

A

Cancer cerebral y ambos linfomas

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25
Q

Inhibidor topoisomerasa

A

Irinotecan

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26
Q

Abs irinotecan

A

IV

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27
Q

Mec accion irinotecan

A

Interfiere accion enzima topoisomerasas

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28
Q

Único met hepat hidrolisis
Que fx

A

Irinotecan

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29
Q

Toxic
Hemato y digestivo

A

Melfan
Irinotecan

30
Q

Toxic irinotecan

A

Gasto y hemato

31
Q

Usi irinotecan

A

Carcinoma metástasis
Cancer esófago
Páncreas
Cuello uterino

32
Q

Fx antimetabolitos

A

Metrotrexato
Aziatropina
Mercaptopurina
Fluorouracilo
Fludarabina

33
Q

Antimetanolito
Fx antifolato

A

Metotrexato

34
Q

Mec accion metotrexato

A

Inhibe enzima dihidrofolato
No se forma purina ni pirimidina

35
Q

Toxic metrotrexato

A

Medular
Gástrico
Renal
Pulmonar
Hepat
Cutáneo
Snc

36
Q

Adm vo iv im

A

Meteotrexato

37
Q

Análogo purina

A

Aziatropina
Mercaptopurina

38
Q

Mec acc análogo purina

A

Antagonista met purina inhibe adn
Arn

39
Q

Análogo purina no inhibe mucho arn

A

Mercaptopurina

40
Q

Análogo purina se usa pra profilaxis transplante

A

Aziatropurina

41
Q

Unión prot 20%
Baja
Fx

A

Mercaptopurina

42
Q

Adv de análogos purinas

A

Fiebre
Hematologico
Hematoma
Hemorragia
Escalofríos
Dolor garganta

43
Q

Mercaptopurina + alopurinol

A

aumenta toxic mercaptopurina

44
Q

analogo pirimidas

A

5- flurouracilo

45
Q

5- flurouracilo
analogo pirimidas
mec acc

A

inhibe sintesis base timidina

46
Q

5- flurouracilo
uso

A

colon mama digest recto

47
Q

analogo adenosina

A

fludarabina

48
Q

analogo adenosina
fludarabina

A

inhibe sint adn
impide proliferacion cell

49
Q

analogo adenosina
fludarabina
uso

A

neoplasia linfoma y leucemia

50
Q

analogo adenosina
fludarabina
adv

A

anemia
trombocitopenia
neutropenia

51
Q

derivado palatino

A

cispalatino

52
Q

cispalatino
mec

A

afecta adn polimerasa

53
Q

adm fludarabina

54
Q

cispalatino
adm

55
Q

cispalatino
toxic

A

renal y neuropatia

56
Q

antitumural antibiot

A

bleomicina
actinomicina d

57
Q

bleomicina
mec accion

A

rompe cadena simple o doble

58
Q

antitumural antibiot
soluble en agua
diodisp

A

bleomicina
baja

59
Q

bleomicina uso

A

carcinoma epidermis
tumor germinal
linfomas

60
Q

bleomicina
toxic

A

tos no productvia

61
Q

actinomicina d

62
Q

actinomicina d
toxic

A

gastro
mielosupresion
dermica

63
Q

actinomicina d
uso

A

wilms y niños

64
Q

alcaloides de vinca deriva de

A

catharanthus roseus

65
Q

alcaloides de vinca fx

A

vincristina
vinblastina
vinorelbina

66
Q

alcaloides de vinca
mec acc

A

inhibe div cell cancerosa
actua en tobulina, no se forma huso mitotico

67
Q

alcaloides de vinca
uso

A

cancer
inmunosupresor

68
Q

vincristina
toxic

69
Q

vinblastina
toxci

A

neutropenia

70
Q

vinorelbina
toxic

A

mucosistis

Farma 2 (18 decks)

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