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Farma 2 > Aminoglucosidos > Flashcards

Aminoglucosidos Flashcards

1
Q

Aminoglucosidos son

A

Bactericida

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2
Q

Aminoglucosido más viejo

A

Estreptomicina

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3
Q

Aminoglucosidos limitado por uso v.o y topicos

A

Neomicina y kanamicina

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4
Q

Más usado y 2nd

A

Gentamicina
Amikacina

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5
Q

Caracteristica

A

Muy polar, carga +
Soluble en agua, insoluble lipidos

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6
Q

Activo a ph

A

Alcalino

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7
Q

Incompatible física y quimicamente

A

Betalactamicos

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8
Q

Farmacocinetica

A

Absorcion: nula oral, poco liposolible, muy polar

Administración parenteral

M: no

E: renal y poco bilis

D: liquido amiotico

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9
Q

Que lo hace nefrotoxico

A

La reabsorcion

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10
Q

Mecanismo accion

A

Inhibe irreversible la síntesis de proteina

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11
Q

Unión a proteina plasmatica

A

Escasa

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12
Q

Mecanismo de resistencia 3

A
  1. Enzima inactiva AG (acetilacion y fosforilacion)
  2. Supresión genéricamente una proteina transportadora. IVPS
  3. Supresión por mutacion en proteina de la unidad 30s
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13
Q

Efectos adversos

A

Nefrotoxico y ototoxico
Parálisis respiratorias en alta dosis
Sinergia diuréticos (furosemida)

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14
Q

Nefrotoxicidad se da por

A

Usar más de 5 días
Aumento de dosis en ancianos
Insuficientes renales

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15
Q

Medicamentos más nefrotoxico

A

Neomicina gentamicina tobramicina

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16
Q

Medicamento ototoxicos

A

Amikacina kansmicina y neomicina

Farma 2 (18 decks)

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