Clorafenicol Flashcards

1
Q

Espectro bacteriano

A

Gram +
Gram -
Anaerobicos

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2
Q

Por q se dejo de usar clorafenicol

A

Muy toxico

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3
Q

Unidad ribosomal

A

50 s

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4
Q

Mecanismos de acción

A

Bloqueo de síntesis proteica
Enzima no actúa y detiene formación de peptido

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5
Q

Bactericida con quien

A

H. Influenzae y nesseria meningitis

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6
Q

Biodisponibilidad

A

Alta y buena

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7
Q

Unión a proteina plasmatica

A

Media 50% 25

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8
Q

Atraviesa placenta c/f

A

Cierto

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9
Q

Metabolizmo

A

Alto 90%

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10
Q

Eliminacion

A

Bilis

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11
Q

Administración

A

Topico IV VO

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12
Q

Fda

A

C

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13
Q

Toxicidad hematologica

A

Daño médula osea
Anemia
Trombocitopenia
Leucopenia
Anemia aplasica

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14
Q

Toxicidad RN

A

Sindrome niño gris
Vómitos
Distinción abdominal
Cianosis
Muerte
Stock
Flacidez

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15
Q

Por qué se da el síndrome niño gris

A

No metabólica o conjuga bien el medicamento en el higado

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16
Q

Rara toxicidas

A

Hipersensibilidad
Anemia aplasica

17
Q

Sangrados por alteración de que vit

A

K

18
Q

Inhibe p450

A

Reversiblemente

19
Q

Que da la inhibición p450 y ejemplos

A

Prolongó vida farmaco
Aumenta niveles plasmaticos
Dicumorol, fenitoina, cloprapamida, tolbutamida, ciclosfosfomida

20
Q

Inductores p 450 da y ejemplos

A

Bajo nivel plasmatico y semivida
Barbitúricos fenitoina rimpamicina

21
Q

Indicado para

A

Meningitis bacteriana: pacientes alérgicos penicilina o neumococo resistencia a penicilina

Alternativa tetraciclina
Infección de recuesta. Fiebre recurrente y clomidia

22
Q

Resistencia bacteria por

A

Acetiltransferasa codificada por un plasmado desactiva el farmaco

23
Q

Comerciales

A

Clodex o clofen

24
Q

Clodex uso y presentacion

A

Infección ocular
Ungüento o gotas

25
Q

Interacciones

A

Inhibe acción bactericida fe penicilina y cefalosporina

Aumenta acción antidiabetico y anticoagulantes