neoplasia 106

Question 1

106. ) mutational loss of the RB1 gene leads to :
     a. ) carcinoma of the the oral cavity
     b. ) retinoblastoma
     c. ) neuroblastoma
     d. ) rhabdomyosarcoma
     e. ) lung cancer

Answer 1

b

Question 2

which mutation is involved in the Li Fraumeni syndrome ( multiple cancers everywhere)

a. ) RB gene mutation
b. ) APC mutation
c. ) MSH 2+ 6 , MLH1 mutation
d. ) p53 muattion

Answer 2

d

Question 3

xeroderma pigmentosa (2correct) :

a. ) is a basal cell carcinoma of the epithelium (risk factor)
b. ) is associated with café au lait pigmentation of the skin
c. ) is the inability to repair UV light induced DNA damage
d. ) shows autosomal dominant inheritance (recessive)

Answer 3

AC

Question 4

Ataxia telangiectasis (2 correct):

a. ) mutation in dsDNA repair system leading to dilated brain vessels
b. ) mutation in p53 leading to dilated brain vessels (Li – Fraumeni)
c. ) associated with bone marrow failure
d. ) associated with cerebellar dysfunction

Answer 4

A D

Question 5

Bloom syndrome :

a. ) mutation of the DNA helicase involved in DNA repair resulting in homologous transversion
b. ) mutation of the chromosome integrity system resulting in homologous inversion
c. ) associated with café au lait pigmentationa and teleangiectasis
d. ) associated with bone marrow failure and leukemia

Answer 5

b d

Question 6

most tumor cells originate from clonal expansion of the same progenitor cells
a.) true
b false

Answer 6

true

Question 7

a hydatidiform mole is a malignant neoplasm of the placental epithelium

a. ) true
b. ) false ( benign, in 80 % of cases

Answer 7

false

Question 8

a seminoma is a benning malignancy of the testicular germ cell epithelium

a. ) true
b. ) false ( malignant !)

Answer 8

false

Question 9

correct for malignancies in blood vessels ( 2 correct):

a. ) hemangioma is a benign neoplasma arising from endothelial cells
b. ) hemangioma is a malignant neoplasm arising from endothelial cells
c. ) angiosarcoma is a malignant neoplasm arising from smooth muscle cells
d. ) angiosarcoma is a malignant neoplasm arising from endothelial cells

Answer 9

a d

Question 10

the nevus (birth marks) is the malignant counterpart of the melanoma

a. ) true
b. ) false ( the benign counterpart of the malignant melanom

Answer 10

false

Question 11

Kaposi carcinoma only in association with HIV

a. ) true
b. ) false (HHV 8)

Answer 11

false

Question 12

which of these viruses is carcinogenic ( 3 correct)?

a. ) EBV
b. ) HBV
c. ) HPV
d. ) HTVL-1 (HTLV-1 = leukaemia

Answer 12

all

Question 13

correct for hepatocellular carcinoma (2 correct)

a. ) composed of alternating rows of hepatocytes and sinusoids (doesn’t make any sense)
b. ) oral contraceptives contribte to its initiation (adenomas)
c. ) constitute the most frequent tumor of the liver
d. ) Bile canaliculi wthin the tumor mass (Robbins p638 e9: pseudocanaliculi

Answer 13

c.d

Question 14

most common place of adenocarcinoma

a. ) larynx (carcinoma)
b. ) vagina
c. ) esophagus
d. ) colon

Answer 14

c .d

Question 15

where is the pronounced Virchow lymphnode

a) mediastinum
b) infraclavicular
c) in the right neck
d) left supraclavicular space (from gastric)
e) right axillary

Answer 15

d

Question 16

the most common mammary carcinoma is the so called “ not otherwise classified” ductal
carcinoma
a.) true (invasive ductul carcinoma is the most common one)
b.) false

Answer 16

a

Question 17

the mammary gland carcinoma is the most frequent and also the most lethal cancer in women

a. ) true
b. ) false (lung has the highest mortality

Answer 17

b

Question 18

typical for melanoma EXCEPT :

a. ) initially it spreads horizontally in the epidermis
b. ) initially it spreads vertically in the epidermis (first horizontal, then vertical is optional. 9e p906)
c. ) shows a macroscopic irregular border
d. ) frequently gives metastasis

Answer 18

b

Question 19

the keratinizing squamous cell carcinoma is a benign tumor

a. ) true
b. ) false (its malignant)

Answer 19

b

Question 20

126.) in cervical intraepithelial neoplasia + colon adenoma ( 2 correct )
a.) koilocytosis ( koilocyte is a squamous epithelial cell that has undergone a number of structural
changes, which occur as a result of infection of the cell by HPV)
b.) loss of polarity
c.) hyperchromasia
d.) microinvasion

Answer 20

b.c

Question 21

127. ) which is NOT a paraneoplastic syndrome ?
     a. ) acromegaly
     b. ) cushing syndrome
     c. ) rheumatic endocarditis
     d. ) marantic endocarditis ( nonthrombotic endocarditis esp in adenocarcinoma )

Answer 21

c

Question 22

128. ) typical characteristics on the carcinoid syndrome may be :
     a. ) obstructive constipation
     b. ) watery diarrhea
     c. ) zahnshcer leberinfarct (pseudo hepatic infarction, without necrosis)
     d. ) intermitted hypertension shir

Answer 22

b

Question 23

129. ) which tumor secretes ACTH ?
     a. ) small cell carcinoma
     b. ) large cell carcinoma
     c. ) ovarian carcinoma
     d. ) renal carcinoma

Answer 23

a

Question 24

130. ) which tumors secrte insulin and IGF (insulin like growth factor) ( 2 correct):
     a. ) hepatocellular carcinoma
     b. ) epidermal carcinomas
     c. ) ectodermal carcinomas

d.) mesenchymal sarcomas

Answer 24

a.d

Question 25

131. ) which tumor MOST likely produces PTH ?( 2 correct )
     a. ) renal cell carcinoms
     b. ) small cell carcinoma
     c. ) bronchial carcinoma
     d. ) squamous cell carcinoma

Answer 25

a.d

Question 26

132. ) which of these diseases produces commonly hormons ?
     a. ) small cell carcinoma (ACTH, ADH)
     b. ) squamous cell carcinoma
     c. ) hemartoma
     d. ) adenocarcinoma

Answer 26

a

Question 27

133. ) in which organ will NO leiomyoma develop ?
     a. ) stomach
     b. ) large intestine
     c. ) heart ( leiomyoma = smooth muscle)
     d. ) uterus
     e. ) esophagus

Answer 27

c

Question 28

134. ) in which organ occur metastasis only rarely ?
     a. ) lung
     b. ) brain
     c. ) spleen (and skeletal muscle)
     d. ) bone
     e. ) liver

Answer 28

c

Question 29

135.) cancer metastasis occur in cardiac and skeletal muscle (VERY RARE metastasize) cells because of
their rich vascularization frequently
a.) ture
b.) false

Answer 29

b

Question 30

136. ) which cancer does not give metastasis ? ( 2 correct)
     a. ) adenoma of the pituitary gland
     b. ) basal cell carcinoma of the skin
     c. ) hepatocellular carcinoma
     d. ) CNS – glioma

Answer 30

a.b.c

Question 31

137. ) low 1/3 rectal cancer gives most likely gives metastasis via
     a. ) the vena porta
     b. ) the vena hepatica
     c. ) the vena cava (systemic circulation!)
     d. ) the bartson vein

Answer 31

c.d

Question 32

138. ) which tumors give metastasis via the batson veins (valveless veins) ?
     a. ) breast cancer
     b. ) prostate cancer
     c. ) thyroid cancer
     d. ) liver cnacer

Answer 32

a.b

Question 33

139. ) what is the meaning of „N“ in TNM ?
     a. ) expansion of the invasion
     b. ) lymphnode metastasis (staging)
     c. ) necrosis
     d. ) neoplasia
     e. ) tumor size

Answer 33

b

Question 34

140. ) brain metastasis most commonly originate from sarcomas :
     a. ) true
     b. ) false (carcinoma

Answer 34

b

Question 35

141. ) wilms tumor is one of the most frequent childhood tumors
     a. ) true
     b. ) false (it is the 5th most, 5%)

Answer 35

b

Question 36

142. ) which is NOT a childhood tumor?
     a. ) neuroblastoma
     b. ) hepatoblastoma
     c. ) wilms tumor
     d. ) chronic leukemia
     e. ) retinoblastoma

Answer 36

d

Question 37

143. ) typical for pigment navi (birthmark) EXCEPT :
     a. ) they may be congenital
     b. ) malignant transformation is typical
     c. ) most navi are acquired
     d. ) most navi fade wth age
     e. ) usually are small

Answer 37

b.c

Question 38

144. ) characteristic of Thromboangiitis obliterans ( Burgers disease ) : (2correct)
     a. ) segmental vasculitis of the extremities (hands, feet)
     b. ) prevalence in young women
     c. ) prevalence in young smoking men
     d. ) fibrinoid necrosis

Answer 38

a.c

Question 39

145. ) thrombangiitis obliterance is frequent in
     a. ) smokers
     b. ) congenital heart failure
     c. ) alcoholism
     d. ) contraceptives
     e. ) intake of increased fat

Answer 39

a

Question 40

147. ) in burgers diseases segmental vasculitis of medium sized and small arteries is significant
     a. ) true
     b. ) false

Answer 40

a

Question 41

148. ) which arterial disease can impair the vision ? ( 2 correct)
     a. ) diabetic microangiopathy
     b. ) giant cell arteritis
     c. ) mönebecks sclerosis
     d. ) burgers diseases

Answer 41

a.c

Question 42

149. ) which arteritis shows opthalmic artery involvement and can lead to blindness ( 2correct)
     a. ) giant cell arteritis
     b. ) polyarteritis nodosa
     c. ) Wegener granulomatosis
     d. ) Takayasu arteritis

Answer 42

a.c

Question 43

149. ) which arteritis shows opthalmic artery involvement and can lead to blindness ( 2correct)
     a. ) giant cell arteritis
     b. ) polyarteritis nodosa
     c. ) Wegener granulomatosis
     d. ) Takayasu arteritis

Answer 43

a.d