neoplasia 106 Flashcards
- ) mutational loss of the RB1 gene leads to :
a. ) carcinoma of the the oral cavity
b. ) retinoblastoma
c. ) neuroblastoma
d. ) rhabdomyosarcoma
e. ) lung cancer
b
which mutation is involved in the Li Fraumeni syndrome ( multiple cancers everywhere)
a. ) RB gene mutation
b. ) APC mutation
c. ) MSH 2+ 6 , MLH1 mutation
d. ) p53 muattion
d
xeroderma pigmentosa (2correct) :
a. ) is a basal cell carcinoma of the epithelium (risk factor)
b. ) is associated with café au lait pigmentation of the skin
c. ) is the inability to repair UV light induced DNA damage
d. ) shows autosomal dominant inheritance (recessive)
AC
Ataxia telangiectasis (2 correct):
a. ) mutation in dsDNA repair system leading to dilated brain vessels
b. ) mutation in p53 leading to dilated brain vessels (Li – Fraumeni)
c. ) associated with bone marrow failure
d. ) associated with cerebellar dysfunction
A D
Bloom syndrome :
a. ) mutation of the DNA helicase involved in DNA repair resulting in homologous transversion
b. ) mutation of the chromosome integrity system resulting in homologous inversion
c. ) associated with café au lait pigmentationa and teleangiectasis
d. ) associated with bone marrow failure and leukemia
b d
most tumor cells originate from clonal expansion of the same progenitor cells
a.) true
b false
true
a hydatidiform mole is a malignant neoplasm of the placental epithelium
a. ) true
b. ) false ( benign, in 80 % of cases
false
a seminoma is a benning malignancy of the testicular germ cell epithelium
a. ) true
b. ) false ( malignant !)
false
correct for malignancies in blood vessels ( 2 correct):
a. ) hemangioma is a benign neoplasma arising from endothelial cells
b. ) hemangioma is a malignant neoplasm arising from endothelial cells
c. ) angiosarcoma is a malignant neoplasm arising from smooth muscle cells
d. ) angiosarcoma is a malignant neoplasm arising from endothelial cells
a d
the nevus (birth marks) is the malignant counterpart of the melanoma
a. ) true
b. ) false ( the benign counterpart of the malignant melanom
false
Kaposi carcinoma only in association with HIV
a. ) true
b. ) false (HHV 8)
false
which of these viruses is carcinogenic ( 3 correct)?
a. ) EBV
b. ) HBV
c. ) HPV
d. ) HTVL-1 (HTLV-1 = leukaemia
all
correct for hepatocellular carcinoma (2 correct)
a. ) composed of alternating rows of hepatocytes and sinusoids (doesn’t make any sense)
b. ) oral contraceptives contribte to its initiation (adenomas)
c. ) constitute the most frequent tumor of the liver
d. ) Bile canaliculi wthin the tumor mass (Robbins p638 e9: pseudocanaliculi
c.d
most common place of adenocarcinoma
a. ) larynx (carcinoma)
b. ) vagina
c. ) esophagus
d. ) colon
c .d
where is the pronounced Virchow lymphnode
a) mediastinum
b) infraclavicular
c) in the right neck
d) left supraclavicular space (from gastric)
e) right axillary
d
the most common mammary carcinoma is the so called “ not otherwise classified” ductal
carcinoma
a.) true (invasive ductul carcinoma is the most common one)
b.) false
a
the mammary gland carcinoma is the most frequent and also the most lethal cancer in women
a. ) true
b. ) false (lung has the highest mortality
b
typical for melanoma EXCEPT :
a. ) initially it spreads horizontally in the epidermis
b. ) initially it spreads vertically in the epidermis (first horizontal, then vertical is optional. 9e p906)
c. ) shows a macroscopic irregular border
d. ) frequently gives metastasis
b
the keratinizing squamous cell carcinoma is a benign tumor
a. ) true
b. ) false (its malignant)
b
126.) in cervical intraepithelial neoplasia + colon adenoma ( 2 correct )
a.) koilocytosis ( koilocyte is a squamous epithelial cell that has undergone a number of structural
changes, which occur as a result of infection of the cell by HPV)
b.) loss of polarity
c.) hyperchromasia
d.) microinvasion
b.c
- ) which is NOT a paraneoplastic syndrome ?
a. ) acromegaly
b. ) cushing syndrome
c. ) rheumatic endocarditis
d. ) marantic endocarditis ( nonthrombotic endocarditis esp in adenocarcinoma )
c
- ) typical characteristics on the carcinoid syndrome may be :
a. ) obstructive constipation
b. ) watery diarrhea
c. ) zahnshcer leberinfarct (pseudo hepatic infarction, without necrosis)
d. ) intermitted hypertension shir
b
- ) which tumor secretes ACTH ?
a. ) small cell carcinoma
b. ) large cell carcinoma
c. ) ovarian carcinoma
d. ) renal carcinoma
a
- ) which tumors secrte insulin and IGF (insulin like growth factor) ( 2 correct):
a. ) hepatocellular carcinoma
b. ) epidermal carcinomas
c. ) ectodermal carcinomas
d.) mesenchymal sarcomas
a.d
- ) which tumor MOST likely produces PTH ?( 2 correct )
a. ) renal cell carcinoms
b. ) small cell carcinoma
c. ) bronchial carcinoma
d. ) squamous cell carcinoma
a.d
- ) which of these diseases produces commonly hormons ?
a. ) small cell carcinoma (ACTH, ADH)
b. ) squamous cell carcinoma
c. ) hemartoma
d. ) adenocarcinoma
a
- ) in which organ will NO leiomyoma develop ?
a. ) stomach
b. ) large intestine
c. ) heart ( leiomyoma = smooth muscle)
d. ) uterus
e. ) esophagus
c
- ) in which organ occur metastasis only rarely ?
a. ) lung
b. ) brain
c. ) spleen (and skeletal muscle)
d. ) bone
e. ) liver
c
135.) cancer metastasis occur in cardiac and skeletal muscle (VERY RARE metastasize) cells because of
their rich vascularization frequently
a.) ture
b.) false
b
- ) which cancer does not give metastasis ? ( 2 correct)
a. ) adenoma of the pituitary gland
b. ) basal cell carcinoma of the skin
c. ) hepatocellular carcinoma
d. ) CNS – glioma
a.b.c
- ) low 1/3 rectal cancer gives most likely gives metastasis via
a. ) the vena porta
b. ) the vena hepatica
c. ) the vena cava (systemic circulation!)
d. ) the bartson vein
c.d
- ) which tumors give metastasis via the batson veins (valveless veins) ?
a. ) breast cancer
b. ) prostate cancer
c. ) thyroid cancer
d. ) liver cnacer
a.b
- ) what is the meaning of „N“ in TNM ?
a. ) expansion of the invasion
b. ) lymphnode metastasis (staging)
c. ) necrosis
d. ) neoplasia
e. ) tumor size
b
- ) brain metastasis most commonly originate from sarcomas :
a. ) true
b. ) false (carcinoma
b
- ) wilms tumor is one of the most frequent childhood tumors
a. ) true
b. ) false (it is the 5th most, 5%)
b
- ) which is NOT a childhood tumor?
a. ) neuroblastoma
b. ) hepatoblastoma
c. ) wilms tumor
d. ) chronic leukemia
e. ) retinoblastoma
d
- ) typical for pigment navi (birthmark) EXCEPT :
a. ) they may be congenital
b. ) malignant transformation is typical
c. ) most navi are acquired
d. ) most navi fade wth age
e. ) usually are small
b.c
- ) characteristic of Thromboangiitis obliterans ( Burgers disease ) : (2correct)
a. ) segmental vasculitis of the extremities (hands, feet)
b. ) prevalence in young women
c. ) prevalence in young smoking men
d. ) fibrinoid necrosis
a.c
- ) thrombangiitis obliterance is frequent in
a. ) smokers
b. ) congenital heart failure
c. ) alcoholism
d. ) contraceptives
e. ) intake of increased fat
a
- ) in burgers diseases segmental vasculitis of medium sized and small arteries is significant
a. ) true
b. ) false
a
- ) which arterial disease can impair the vision ? ( 2 correct)
a. ) diabetic microangiopathy
b. ) giant cell arteritis
c. ) mönebecks sclerosis
d. ) burgers diseases
a.c
- ) which arteritis shows opthalmic artery involvement and can lead to blindness ( 2correct)
a. ) giant cell arteritis
b. ) polyarteritis nodosa
c. ) Wegener granulomatosis
d. ) Takayasu arteritis
a.c
- ) which arteritis shows opthalmic artery involvement and can lead to blindness ( 2correct)
a. ) giant cell arteritis
b. ) polyarteritis nodosa
c. ) Wegener granulomatosis
d. ) Takayasu arteritis
a.d
