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immunology > natural immunity > Flashcards

natural immunity Flashcards

1
Q

which of the APR is like an antibody

a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1

A

C- reactive protein
- acts like an antibody because it is capable in
opsonization
precipitation
agglutination
activation of complement by classical pathway

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2
Q

which of the ff APR is increased in bacterial infection

a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1

A

Serum amyloid A

  • increase significantly more in BACTERIAL INFECTION than viral infection
  • also increased in CAC ( chronic infalammation, Atherosclerosis, Cancer)
  • contribute to LOCALIZED INFALMATION IN CORONARY ARTERY DISEASE
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3
Q

which of the following is BEST indicator of acute inflammation

a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1

A

C- reactive protein

  • MOST WIDELY MONITORED of APR
  • BEST INDICATOR OF ACUTE INFLAMMATION
  • the main substrate is PHOSPHOCHOLINE
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4
Q

which of the following is risk factor for myocardial infarction and ischemic stroke

a. hs crp
b. alpha antitrypsin 1
c. ceruloplasmin
d. serum amyloid a

A

HS-CRP

risk factor for myocardial infarction and ischemic stroke

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5
Q

which of the following is associated with HDL CHOLESTEROL

a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1

A

serum amyloid a

  • associated with HDL CHOLESTEROL
  • ACTS AS CHEMICAL MESSENGER
  • increase significantly more in BACTERIAL INFECTION than viral infection
    • also increased in CAC ( chronic infalammation, Atherosclerosis, Cancer)
    • contribute to LOCALIZED INFALMATION IN CORONARY ARTERY DISEASE
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6
Q

LACK OF MANNOSE BINDING PROTEIN HAS BEEN ASSOCIATED WITH?

A. pre mature emphysema

b. juvenile cirrhosis
c. recurrent yeast infection
d. coronary artery disease

A

Alpha antitrypsin 1
- pre mature emphysema and Juvenile cirrhosis

lack of MBP
- recurrent yeast infection

SAA
- coronary artery disease

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7
Q

which of the following is calcium dependent

a. CRP
b. SAA
c. MBP
d. alpha 1 antitrypsin

A

Mannose binding protein
- a trimer that acts as opsonin which is calcium dependent
- widely distributed in mucosal surfaces throughout the body
lack of MBP - recurrent yeast infection

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8
Q

which of the APR has similarity with complement component c1q

a. CRP
b. SAA
c. MBP
d. alpha 1 antitrypsin

A

Mannose binding protein
has a similarity with complement component c1q, as a binding activates the complement cascade and heps to promote phagocytosis

CRP
- smilar to antibodies

Serum amyloid a
- simlar to cytokines

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9
Q

which of the folowing APR regulate sin proinflammatory cytokines such as TNF , IL-1 and IL 6

a. CRP
b. SAA
c. MBP
d. alpha1 antitrypsin

A

alpha 1 antitrypsin

  • a general plasma inhibits protease
  • regulate sin proinflammatory cytokines such as TNF , IL-1 and IL 6
  • deficiency can lead to PREMATURE EPHYSEMA AND JUVENILE CIRRHOSIS
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10
Q

which of the apr acts as FERROXIDASE

a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin

A

Ceruloplasmin

  • principal copper transporting protein
  • acts a FERROXIDASE\
  • increase copper in tissue -> WILSON’ S DISEASE
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11
Q

acts as antioxidant

a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin

A

haptoglobin
- acts an antioxidant

Ceruloplasmin
- acts as ferroxidase

MBP
- acts as complment cascade 1

SS
- acts as cytokines

CRP
- antibodies

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12
Q

it binds irreversibly to free hemoglobin releases

a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin

A

haptoglobin

  • it binds irreversibly to free hemoglobin releases
  • acts as antioxidant to provide protection against oxidative damage mediated to free hemoglobin
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13
Q

what is the test for chemotaxis

a. phosphocholine
b. CRP
c. Boyen chamber assay

A

BOYDEN CHAMBER ASSAY

- test for chemotaxis

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14
Q

migration toward to the site of chemotaxis

a. positive chemotaxis
b. negative chemotaxis
c. nota
d. aota

A

positive chemotaxis
- towars

negative
- away

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15
Q

whichof the following process of phagocytosis is process by which cells tend to move in a certain direction

a. initiation
b. chemotaxis
c. engulfment
d. digestion

A

chemotaxis

- process by which cells tend to move in a certain direction

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16
Q

which of the following syndrome has a abnormal random and chemotactic activity

a. hyperimmunoglobin e
b. job syndrome
c. lazy leukocyte syndrome
d. wilson’s diesease

A

job syndrome and hyperimmunoglobulin e
- abnormal chemotactic activity

Lazy leukocyte syndrome
- abnormal random and chemotactic activity

17
Q

steps on phagocytosis
formation of the ________; contents of the lysosome are emptied into this membrane bound space

a. phagosome
b. phagolysozome
c. digestion
d. excretion

A

formation of the PHAGOLYSOZOME; contents of the lysosome are emptied into this membrane bound space

18
Q

which of this following step is the first step

a. adherence
b. fusion
c. phagosome formation
d. chemotaxis
e. digestion and destruction
f. engulfment

A

phagocytosis can be divided into 6 stages (turgeon)

  Chemotaxis
  adherence
  engulfment
  phagosome formation
  fusion
  digestion and destruction
19
Q

what are the two type of killing

a. direct
b. indirect
c. oxygen dependent
d. oxygen independent

A

types of phagocytosis

  1. direct - via PRRP
  2. indirect - via opsonins

ways of killing

  1. oxygen dependent / respiratory burst
  2. oxygen independet
20
Q

which of the following is not a phagocytic cell

a. basophil
b. neutrophil
c. lymphocyte
d. dendritic cell

A

phagocytic cell (BEN MD)
B - BASOPHIL
E- EOSINOPHIL
N- NEUUTROPHIL

M- MONOCYTE/ MACROPHAGE
D- DENDRITIC CELLS

ANS: LYMPHOCYTE OR MAST CELL

21
Q

NADPH OXIDASE DYSFUNCTION

A. JOB SYNDROME
B. LAZY LEUKOCYTE SYNDROME
C. CHRONIC GRANULOMATOUS DISEASE
D. WILSON’S DISEASE

A

CGD
- lacks of NADPHoxidase

  • impaired respirtaory burst
22
Q

they are chemical messengers that cause cells to migrate in a particular direction

a. fusion
b. chemotaxis
c. destruction
d. engulfment

A

chemotaxis

23
Q

produced by neutrophils, certain macrophage populations and paneth cells of the small intestine. this class of defensin is belleived to disrupt the microbial membrane

a. beta lysin
b. alpha defensinsq
c. properdin
d. beta defensins

A

ans: alpha defensin
- certain macrophage population and paneth cells of the small intestine
- believed to disrupt the microbial membrane

beta lysin

  • epithelial cell lining
  • increase resistance of epithelial cell to colonization
24
Q

produced by neutrophils, as well as epithelial cell lining the various organs , including the bronchial tree and genitourinary system

a. beta lysin
b. alpha defensinsq
c. properdin
d. beta defensins

A

ans: beta defensin

alpha defensins

  • certain macrophage population and paneth cells of the small intestine
    • believed to disrupt the microbial membrane

beta lysin

  • epithelial cell lining
  • increase resistance of epithelial cell to colonization
25
Q

surface receptprs that promotes cell to cell interaction

a. properdin
b. beta lysin
c. integrins
d. adherence

A

integrins
- surface receptor that promotes cell tocell interaction

properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium

beta lysin
- heat stable cationic substance that released by platelet during coagulation

26
Q

bactericidal and viricidal protein in the presence of c3 component and magnesium

a. properdin
b. beta lysin
c. integrins
d. adherence

A

integrins
- surface receptor that promotes cell tocell interaction

properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium

beta lysin
- heat stable cationic substance that released by platelet during coagulation

27
Q

heat stable cationic substance that released by platelet during coagulation

a. properdin
b. beta lysin
c. integrins
d. adherence

A

integrins
- surface receptor that promotes cell tocell interaction

properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium

beta lysin
- heat stable cationic substance that released by platelet during coagulation

immunology (13 decks)

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