natural immunity Flashcards
which of the APR is like an antibody
a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1
C- reactive protein
- acts like an antibody because it is capable in
opsonization
precipitation
agglutination
activation of complement by classical pathway
which of the ff APR is increased in bacterial infection
a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1
Serum amyloid A
- increase significantly more in BACTERIAL INFECTION than viral infection
- also increased in CAC ( chronic infalammation, Atherosclerosis, Cancer)
- contribute to LOCALIZED INFALMATION IN CORONARY ARTERY DISEASE
which of the following is BEST indicator of acute inflammation
a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1
C- reactive protein
- MOST WIDELY MONITORED of APR
- BEST INDICATOR OF ACUTE INFLAMMATION
- the main substrate is PHOSPHOCHOLINE
which of the following is risk factor for myocardial infarction and ischemic stroke
a. hs crp
b. alpha antitrypsin 1
c. ceruloplasmin
d. serum amyloid a
HS-CRP
risk factor for myocardial infarction and ischemic stroke
which of the following is associated with HDL CHOLESTEROL
a. CRP
b. SAA
c. MBP
d. alpha antitrypsin 1
serum amyloid a
- associated with HDL CHOLESTEROL
- ACTS AS CHEMICAL MESSENGER
- increase significantly more in BACTERIAL INFECTION than viral infection
- also increased in CAC ( chronic infalammation, Atherosclerosis, Cancer)
- contribute to LOCALIZED INFALMATION IN CORONARY ARTERY DISEASE
LACK OF MANNOSE BINDING PROTEIN HAS BEEN ASSOCIATED WITH?
A. pre mature emphysema
b. juvenile cirrhosis
c. recurrent yeast infection
d. coronary artery disease
Alpha antitrypsin 1
- pre mature emphysema and Juvenile cirrhosis
lack of MBP
- recurrent yeast infection
SAA
- coronary artery disease
which of the following is calcium dependent
a. CRP
b. SAA
c. MBP
d. alpha 1 antitrypsin
Mannose binding protein
- a trimer that acts as opsonin which is calcium dependent
- widely distributed in mucosal surfaces throughout the body
lack of MBP - recurrent yeast infection
which of the APR has similarity with complement component c1q
a. CRP
b. SAA
c. MBP
d. alpha 1 antitrypsin
Mannose binding protein
has a similarity with complement component c1q, as a binding activates the complement cascade and heps to promote phagocytosis
CRP
- smilar to antibodies
Serum amyloid a
- simlar to cytokines
which of the folowing APR regulate sin proinflammatory cytokines such as TNF , IL-1 and IL 6
a. CRP
b. SAA
c. MBP
d. alpha1 antitrypsin
alpha 1 antitrypsin
- a general plasma inhibits protease
- regulate sin proinflammatory cytokines such as TNF , IL-1 and IL 6
- deficiency can lead to PREMATURE EPHYSEMA AND JUVENILE CIRRHOSIS
which of the apr acts as FERROXIDASE
a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin
Ceruloplasmin
- principal copper transporting protein
- acts a FERROXIDASE\
- increase copper in tissue -> WILSON’ S DISEASE
acts as antioxidant
a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin
haptoglobin
- acts an antioxidant
Ceruloplasmin
- acts as ferroxidase
MBP
- acts as complment cascade 1
SS
- acts as cytokines
CRP
- antibodies
it binds irreversibly to free hemoglobin releases
a. CRP
b. SAA
c. Ceruloplasmin
d. haptoglobin
haptoglobin
- it binds irreversibly to free hemoglobin releases
- acts as antioxidant to provide protection against oxidative damage mediated to free hemoglobin
what is the test for chemotaxis
a. phosphocholine
b. CRP
c. Boyen chamber assay
BOYDEN CHAMBER ASSAY
- test for chemotaxis
migration toward to the site of chemotaxis
a. positive chemotaxis
b. negative chemotaxis
c. nota
d. aota
positive chemotaxis
- towars
negative
- away
whichof the following process of phagocytosis is process by which cells tend to move in a certain direction
a. initiation
b. chemotaxis
c. engulfment
d. digestion
chemotaxis
- process by which cells tend to move in a certain direction
which of the following syndrome has a abnormal random and chemotactic activity
a. hyperimmunoglobin e
b. job syndrome
c. lazy leukocyte syndrome
d. wilson’s diesease
job syndrome and hyperimmunoglobulin e
- abnormal chemotactic activity
Lazy leukocyte syndrome
- abnormal random and chemotactic activity
steps on phagocytosis
formation of the ________; contents of the lysosome are emptied into this membrane bound space
a. phagosome
b. phagolysozome
c. digestion
d. excretion
formation of the PHAGOLYSOZOME; contents of the lysosome are emptied into this membrane bound space
which of this following step is the first step
a. adherence
b. fusion
c. phagosome formation
d. chemotaxis
e. digestion and destruction
f. engulfment
phagocytosis can be divided into 6 stages (turgeon)
Chemotaxis adherence engulfment phagosome formation fusion digestion and destruction
what are the two type of killing
a. direct
b. indirect
c. oxygen dependent
d. oxygen independent
types of phagocytosis
- direct - via PRRP
- indirect - via opsonins
ways of killing
- oxygen dependent / respiratory burst
- oxygen independet
which of the following is not a phagocytic cell
a. basophil
b. neutrophil
c. lymphocyte
d. dendritic cell
phagocytic cell (BEN MD)
B - BASOPHIL
E- EOSINOPHIL
N- NEUUTROPHIL
M- MONOCYTE/ MACROPHAGE
D- DENDRITIC CELLS
ANS: LYMPHOCYTE OR MAST CELL
NADPH OXIDASE DYSFUNCTION
A. JOB SYNDROME
B. LAZY LEUKOCYTE SYNDROME
C. CHRONIC GRANULOMATOUS DISEASE
D. WILSON’S DISEASE
CGD
- lacks of NADPHoxidase
- impaired respirtaory burst
they are chemical messengers that cause cells to migrate in a particular direction
a. fusion
b. chemotaxis
c. destruction
d. engulfment
chemotaxis
produced by neutrophils, certain macrophage populations and paneth cells of the small intestine. this class of defensin is belleived to disrupt the microbial membrane
a. beta lysin
b. alpha defensinsq
c. properdin
d. beta defensins
ans: alpha defensin
- certain macrophage population and paneth cells of the small intestine
- believed to disrupt the microbial membrane
beta lysin
- epithelial cell lining
- increase resistance of epithelial cell to colonization
produced by neutrophils, as well as epithelial cell lining the various organs , including the bronchial tree and genitourinary system
a. beta lysin
b. alpha defensinsq
c. properdin
d. beta defensins
ans: beta defensin
alpha defensins
- certain macrophage population and paneth cells of the small intestine
- believed to disrupt the microbial membrane
beta lysin
- epithelial cell lining
- increase resistance of epithelial cell to colonization
surface receptprs that promotes cell to cell interaction
a. properdin
b. beta lysin
c. integrins
d. adherence
integrins
- surface receptor that promotes cell tocell interaction
properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium
beta lysin
- heat stable cationic substance that released by platelet during coagulation
bactericidal and viricidal protein in the presence of c3 component and magnesium
a. properdin
b. beta lysin
c. integrins
d. adherence
integrins
- surface receptor that promotes cell tocell interaction
properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium
beta lysin
- heat stable cationic substance that released by platelet during coagulation
heat stable cationic substance that released by platelet during coagulation
a. properdin
b. beta lysin
c. integrins
d. adherence
integrins
- surface receptor that promotes cell tocell interaction
properdin
- bactericidal and viricidal protein in the presence of c3 component and magnesium
beta lysin
- heat stable cationic substance that released by platelet during coagulation
