autoimmune disorders Flashcards
proteins has ability to bind to both mhc class II molecules and TCRs
a. estrogens
b, androgens
c. prolactin
d. superantigens
superantigens - protein produced by various microbes that have the ability to bind class II mhc molecules and TCRs, regaardless of their antigen specificity
Estrogen
- tend to direct immune system in favor to T ype 2 helper cells (Th2) response, resulting in more B cell activation and antibody production
androgens
- favor to Th1 response to activtaion of CD8+ T cells
prolactin
- stimulates production of milk
what are the factors that influence the development of autoimmunity
a. age
b. genetic factor
c. exogenous factor
d. sex
e. aota
factors that influence the development of autoimmunity
- genetic factor
- patients ages
- exogenous factor
Chronic inflammatory autoimmune disease including swelling of joints
a. rheumatoid arthritis
b. systemic lupus erythematosus
c. Sjogren’s syndrome
d. Good Pasteur syndrome
SLE
- Chronic inflammatory autoimmune disease including swelling of joints
- systemic and multi organ autoimmune disorder
- strongly associated with HLA DR- 3
substrate used in testing FANA TESTING
A. mouse spleen
b. mouse kidney
c. Hep-2 cells
d. Crithidia luciliae
fluorescent anti nuclear antibody test (FANA)
- Hep-2 cells
- . mouse Kidney cell
- Crithidia luciliae
antibodies more specific to SLE
a. anti dsDNA
b. anit ssDNA
c. Anti Sm
d. autioantibody- anti centromere
Anti - dsDNA
- MORE SPECIFIC ON SLE
Anti ssDNA
- sle, MANY OTHER DISEASE
Anti Sm
- DIAGNOSTIC for SLe
chronic , symmetric and erosive arthritis of the peripheral joint
a. rheumatoid arthritis
b. systemic lupus erythematosus
c. Sjogren’s syndrome
d. Good Pasteur syndrome
rheumatoid arthritis
- chronic , symmetric and erosive arthritis of the peripheral joint
- also affect multiple organs such as lungs and hearts
- strongly associated with HLA DR4
NATURE OF RHEUMATOID FACTOR
A. an IgM directed to Fab of IgG
b. an IgG directed to Fc of Igm
c. an IgM directed to Fc of IgG
detection of RF
- manual agglutination test uses charchoal or latex particles coated with IgG
- an IgM directed to Fc of IgG
(MaCa Gago)
methods- sheep cell agglutination test
- latex fixation test
- sensitized alligator erythrocytes test
- bentonite flocculation test
- labelled immunoassay
what is titer in rheumatoid factor that is negative
a. with 80 or greater
b. 20 - 40
c. no agglutination at 1:20
d. nota
titer of 80 or greater -> positive
20-40
- weakly positive
1:20
negative
which of the following disease has antibodies Anti - glutamic acid decarboxylase
a. type 1 dm
b. grave’s disease
c. hashimoto’s disease
d, pernicious anemia
Type 1 Dm
- selective destruction of the insulin producing b cell
> antibodies
- Anti - glutamic acid decarboxylase (GAD)
- Anti insulin antibodies
which of the following disease has antibodies Anti - TSH receptor antibodies
a. type 1 dm
b. grave’s disease
c. hashimoto’s disease
d, pernicious anemia
graves disease
- unregulated secretion of T3 and T4 due to stimulation of TSH receptor to antibody
> antibodies
- ANTI TSH RECEPTOR NATIBODIES
- anti thyroid peroxidase
- anti thyroglobin antibodies
which of the following disease has antibodies Anti - anti microsomal antibodies
a. type 1 dm
b. grave’s disease
c. hashimoto’s thyrodoitis
d, pernicious anemia
Hashimoto’s thyroiditis
- DESTRUCTION of the thyroid gland
> antibodies
- ANTI MICROSMAL ANTIBODIES
- anti thyroglobulin antibodies
- anti thyroid peroxidase
which of the following disease has antibodies Anti - parietal cells
a. type 1 dm
b. grave’s disease
c. hashimoto’s disease
d, pernicious anemia
Pernicious anemia
- destruction of parietal cells
- leading to intrinsic factor deficiency
> antibodies
- anti parietal cell - anti intrinsic factor
which of the following disease has antibodies Anti glomerular basement membrane
a. Good Pasteur syndrome
b. grave’s disease
c. hashimoto’s disease
d, primary biliary cirrhosis
Good Pasteur Syndrome
which of the following disease has antibodies Anti smooth muscle antibody
a. Good Pasteur syndrome
b. autoimmune hepaatitis
c. hashimoto’s disease
d, primary biliary cirrhosis
autoimmune hepatitis
- known as CHRONIC ACTIVE HEPATITIS
- ANTIBODIES : anti smooth muscle antibody
which of the following disease has antibodies Anti mitochondria
a. Good Pasteur syndrome
b. chronic active hepatitis
c. myasthenia gravis
d, primary biliary cirrhosis
primary biliary cirrhosis
- an autoimmune cholestatic liver disease
- antibodies : Anti mitochondial
