antibodies and immunoglobulins Flashcards
substance produced in response to antigenic stimulation and capable to specific interaction with provoking immunogen
a. antigen
b. antibodies
c. epitopes
c. immunogen
antibodies
antibodies are held together by
a. non covalent bonds
b. disulfide interchain bridges
c. aota
d. nota
antibodies are held together by
non covalent bonds and disulfide interchain bridges
the basic structure of immunoglobulins was elucidated in 1959 - 1960 by the efforts of two men
a. gerald edelman
b. robert porter
c. alfred nisonoff
d. niels jerne
GERALD EDELAMAN AND ROBERT PORTER
- BASIC STRUCTURE OF IMMUNOGLOBULINS
CLONAL SELECTION
- NIELS JERNE AND MACFARLANE BURNET
PAPAIN
- PORTER’S WORK
PEPSIN
- ALFRED NISONOFF
which of this two cleave is separated into three fragments
a. papain
b. pepsin
papain
- porter’s work
- separated by 3 fragments
- 2fab + 1 Fc
pepsin
- alfred nisonoff
separated by 2 fragments
- f(ab)2 + fc’
the amino terminal end of each chain contains the
a. variable region
b. constant region
c. crystallizable
d. antigen binding
the amino terminal end of each chain contains the VARIABLE REGION
the carboxyl terminal end of each chain contains the
CONSTANT REGION
where does heavy chain located
a. ch1
b. ch2
c. proline
d. ch3
heavy chain
- located : CH1 and CH2
- it has HIGH CONTENT OF PROLINE
what chain does bence jones protein belongs
a. heavy chain
b. light chain
light chain
- BJP : light chain found in urine pf patients with MULTIPLE MYELOMA
what immunoglobulins has a percent of total immunoglobulin 70-75%
a. IgG
b. IgA
c. IgM
d. IgD
e. IgE
percent of total immunoglobulin
a. IgG - 70-75%
b. IgA - 10-15
c. IgM - 10
d. IgD - <1
e. IgE - 0.002
which of the immunoglobulin has a longer shelf life
a. IgG
b. IgA
c. IgM
d. IgD
e. IgE
shelf life
a. IgG - 23-25 days
b. IgA - 5 days
c. IgM - 6 days
d. IgD - 1-3 dyas
e. IgE - 2 -3 days
how many binding sites does a pentamer has
a. 5
b. 10
c. 4
d. 2
pentamer/ 5 structure
- 10 binding sites
dimer / 2 structures
- 4 binding sites
monomer / structures
- 2 binidng sites
which of the subclass of IgG has a fixation complement
a. IgG 1
b. IgG2
c. IgG3
d. IgG4
fixation of complement
EXCEPT IgG4
IgG 3 >1 > 2
which of the subclass of IgG cannot cross the placenta
a. IgG 1
b. IgG2
c. IgG3
d. IgG4
providing immunity for the newborn , it can cross placenta EXCEPT IgG 2
IgG 1> 3> 4
it diffuses more readily than other immunoglobulin into the extravascular spaces
a. IgG
b. IgA
c. IgM
d. IgD
e. IgE
IgG- extravascular psaces
IgM - confined to the intravascular pool because of its large size
warm antibodies
a. IgG
b. IgA
c. IgM
d. IgD
e. IgE
IgG
cold antibodies
a. IgG
b. IgA
c. IgM
d. IgD
e. IgE
IgM
M- malamig
