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immunology > cytokines > Flashcards

cytokines Flashcards

1
Q

cytokines that are produced by the T cells are known?

a. monokines
b. lymphokines
c. nota
d. aota

A

cytokines that are produced by the T cells are known
- LYMPHOKINES

cytokines that are produced by the monocytes or macrophages are known
- MONOKINES

cytokines are NOT produced by B cells

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2
Q

a single cytokine have many different actions

a. pleiotropy
b. redundancy
c. synergestic reaction
d. antagonism

A

pleiotropy

- single cytokines have many different actions

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3
Q

different cytokines activate some of the same pathway and genes

a. pleiotropy
b. redundancy
c. synergestic reaction
d. antagonism

A

redundancy

  • DIFFERENT cytokines activate SOME OF THE SAME PATHWAY AND GENES
  • this redundacy may be explained by the fact that MANY CYTOKINES SHARE RECEPTOR SUBUNIT
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4
Q

cytokines often acts as networks; if the effects of complement and enhance each other

a. pleiotropy
b. redundancy
c. synergestic reaction
d. antagonism

A

synergestic reaction

- acts as networks ; if the effects is COMPLEMENT AND ENHANCEEACH OTHER

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5
Q

A cytokine that may counteract the action of another cytokine

a. pleiotropy
b. redundancy
c. synergestic reaction
d. antagonism

A

antagonism

- cytokine COUNTERACT action of ANOTHER cytokine

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6
Q

a massive overproduction and dysregulation of cytokines

a. cytokine storm
b. redundancy
c. synergestic reaction
d. antagonism

A

cytokine storm

  • MASSIVE OVERPRODUCTION AND DYSREGULATION OF CYTOKINES produced by hyperstimulation of the immune response or HYPERCYTOKINEMIA
  • may LEAD TO SHOCK, MULTIORGAN FAILURE OR EVEN DEATH
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7
Q

which is not a MAJOR ANTI - INFLAMMATOR CYTOKINES

a, TGF - BETA
B. IL - 10
C. IL- 13
D. IL - 35
E. NOTA
A

answer: e. nota

MAJOR ANTI INFLAMMATORY CYTOKINES
  -  TGF - BETA
  - IL - 10
 - IL 13
  IL 35
MAJOR INFLAMMATORY CYTOKINES
  - TNF -A
     IL 1
     IL 6
     IFN GAMMA
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8
Q

induces production the production vascular cell adhesion molecules

a. IL 1
B. IL -2
C. IL 3
D. IFN APHA

A

IL 1

induces production the production vascular cell adhesion molecules as well as cytokines and IL 6

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9
Q

acts as endogenous pyrogen

a. IL 1
B. IL -2
C. IL 3
D. IFN APHA

A

IL 1

  • induces production the production vascular cell adhesion molecules as well as cytokines and IL 6
  • acts as endogenous pyrogen (induces fever) in the APR through its action in the hypothalamus
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10
Q

it drives the growth and differentiation of t cell and b cell and induces lytic activity of nk cells

a. IL 1
B. IL -2
C. IL 3
D. IFN APHA

A

IL-2

  • T cell and B cell growth
  • it drives the growth and differentiation of t cell and b cell and induces lytic activity of nk cells
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11
Q

this interleukin can activate proliferation of Th2 cells and helps to generate IgG1 and IgE producing cells

a. IL 1
B. IL -2
C. IL 3
D. IFN APHA

A

IL-2

  • T cell and B cell growth
  • it drives the growth and differentiation of t cell and b cell and induces lytic activity of nk cells
  • can activate proliferation of Th2 cells and helps to generate IgG1 and IgE producing cells
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12
Q

it promotes HEMATOPOIESIS

a. IL 1
B. IL -2
C. IL 3
D. IFN APHA

A

IL- 3

  • known as MULTI COLONY STIMULATING SYSTEM
  • promotes : HEMATOPOIESIS
  • stimultates (MEL) MYELOID, ERYTHROID and LYMPHOID
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13
Q 
its major function is production of ACUTE PHASE REACTANTS
a. IL 6
B. TNF - A
C. IL 3
D. IFN APHA
A

IL-6

  • its ​major function is production of ACUTE PHASE REACTANTS
  • RENAL STOEN MARKER
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14
Q

CAN BE USED AS A RENAL STONE MARKER

a. IL 6
B. TNF - A
C. IL 3
D. IFN APHA

A

IL-6

  • its ​major function is production of ACUTE PHASE REACTANTS
  • RENAL STOEN MARKER
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15
Q

known as CACHECTIN

a. IL 6
B. TNF - A
C. IL 3
D. IFN APHA

A

TNF -A

  • known as CACHECTIN
  • PRODUCED by MACROPHAGES AND NK CELLS
  • LIPOPOLYSACCARIDE FOUN IN GRAM NEGATIVE BACTERIA
  • SECRETION OF HIGHER LEVELS MAY LEAD TO SEPTIC SHOCK
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16
Q

for killing and endothelia production

a. IL 6
B. TNF - A
C. TNF - B
D. IFN APHA

A

TNF BETA

  • KNOWS AS LYMPHOTOXIN
  • PRODUCED BY T CELLS
  • FOR KILLING AND ENDOTHELIA PRODUCTION
17
Q

has been used to treat hepatitis C and kaposi sarcoma

a. TNF- A
b. TNF - B
c. IFN -A
d. IFN - B

A

TYPE 1 IFN - ALPHA

  • activates NK CELLS
  • enhance the expression of mhc class 1
  • increasing recognition and killing viral infected cells
  • used to treat hepatitis C and kaposi sarcoma as well as certain leukemia and lymphoma
18
Q

effectious in treating multiple sclerosis

a. TNF- A
b. TNF - B
c. IFN -A
d. IFN - B

A

type 1 IFN - BETA

  • (FIBROBLAST IFN / EPITHELIAL CELL IFN) - secreted by fibroblasts
  • effectious in treating multiple sclerosis
19
Q

most potent activator of macrophages and boosts their tumoricidal activity

a. TNF- A
b. IFN - GAMMA
c. IFN -A
d. IFN - B

A

TYPE 2 IFN- GAMMA

  • secreted by t cells and nk cells
  • principal molecule produced by Th1 cells, which AFFECT RNA EXPRESSION LEVELS
  • MOST POTENT ACTIVATOR OF MACROPHAGES AND BOOSTS THEIR TUMORICIDAL ACTIVITY
20
Q

MAJOR MACROPHAGE ACTIVATOR

a. TNF- A
b. IFN - GAMMA
c. IFN -A
d. IFN - B

A

TYPE 2 IFN- GAMMA

  • secreted by t cells and nk cells
  • principal molecule produced by Th1 cells, which AFFECT RNA EXPRESSION LEVELS
  • MOST POTENT ACTIVATOR OF MACROPHAGES AND BOOSTS THEIR TUMORICIDAL ACTIVITY
  • MAJOR MACROPHAGE ACTIVATOR
21
Q

involves in the regulation and activation of CD 4+ Th1 cells, CD8+ cytotoxic lymphocytes and nk cells

a. TNF- A
b. IFN - GAMMA
c. IFN -A
d. IFN - B

A

TYPE 2 IFN- GAMMA

  • secreted by t cells and nk cells
  • principal molecule produced by Th1 cells, which AFFECT RNA EXPRESSION LEVELS
  • MOST POTENT ACTIVATOR OF MACROPHAGES AND BOOSTS THEIR TUMORICIDAL ACTIVITY
  • MAJOR MACROPHAGE ACTIVATOR
  • involves in the regulation and activation of CD 4+ Th1 cells, CD8+ cytotoxic lymphocytes and nk cells
22
Q

regulates the expression of CD 8 IN CD 4-CD8 THYMOCYTES

a. TGF - BETA
b. IFN - GAMMA
c. IFN -A
d. IFN - B

A

TGF BETA
- regulates the expression of CD 8 IN CD 4-CD8 THYMOCYTES

TYPE 2 IFN- GAMMA
- involves in the regulation and activation of CD 4+ Th1 cells, CD8+ cytotoxic lymphocytes and nk cells

immunology (13 decks)

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