complement system Flashcards
acts as powerful opsonin
a. C3b
b. C5a
c. C3a
d. C5a
acts as powerful opsonin
- C3 b -> enhance of facilitate phagocytosis
acts as chemotaxin
- C5a
acts as anaphlatoxin
- C3a, C4a, and C5a -> promote inflammation
acts as chemotaxin
a. C3b
b. C5a
c. C3a
d. C5a
acts as powerful opsonin
- C3 b -> enhance of facilitate phagocytosis
acts as chemotaxin
- C5a
acts as anaphlatoxin
- C3a, C4a, and C5a -> promote inflammation
what are the electrolytes need for activation of complement
a. calcium
b. magnesium
c. chloride
d. potassium
ions involved
- Calcium and Magnesium
is a small polypetide that causes INCREASED VASCULAR PERMEABILITY, CONTRACTION OF SMOOTH MUSCLE AND RELEASE OF HISTAMINE from basophils and mast cell
a. opsonization
b. phagocytosis
c. anaphylatoxin
d. nota
anaphylatoxin
- small polypeptide
> causes :
increased vascular permeability
contraction of smooth muscle
release of histamine
in classical pathway :
binds to Fc of IgG and IgM
a. C1q
b. C1r
c. C1s
d. C4
c1q - binds to Fc of IgM and IgG
c1r - activates the C1s
C1s - cleaves C4 and C2
C4 - is part of c3 convertase (C4B)
in classical pathway:
it is KEY INTERMEDIATE TO ALL PATHWAY AND MOST CONCETRATED COMPLEMENT COMPONENT
a. c2
b. C3
c. C5
d. C6
c2 - binds to C4b - from C3 convertase
C3 - KEY INTERMEDIATE TO ALL PATHWAY AND MOST CONCETRATED COMPLEMENT COMPONENT
C5 - initiates MEMBRANE ATTACK COMPLEX (MAC)
in classical pathway
start to pore formation on membrane
a. c6
b. c7
c. c8
d. c9
c6 - BINDS TO c5B In MAC
C7 - binds to C5bC6 in MAC
c8 - start pore formation
c9 - polymerizes CELL LYSIS
alternative pathway
stabilizes C3 convertase and C5 convertase in the presence of magnesium
a. factor B
b. factor D
c. properdin
alternative pathway
Factor B
- binds C3B to from c3 convertase
Fcator D
- cleaves factor b
properdin
- stabilizes C3 convertase and C5 convertase in the presence of magnesium
MBL pathway
binds to mannose
a. MBL
b. MASP1
c. MASP2
MBL pathway
MBL
- binds to mannose
MASP -1
- helps to cleave C4 nad C@
MASP 2
- cleaves C4 and C2
which of the following deficient component is associated with athersclerosis
a. c2
b. c3
c. c4
d. c5-c8
C2
- lupus like syndrome
- recurrent infection
- ATHEROSCLEROSIS
- MOST COMMON DEFICIENCY
which of the following deficient component is associated with GLOMERULONEPHRITIS
a. c2
b. c3
c. c4
d. c5-c8
C3
- SEVERE RECURRENT INFECTION
- GLOMERULONEPHRITIS
- MOST SEVERE DEFICIENCY
which of the following deficient component is associated with NO KNOWN DISEASE
A. C5-C8
b. C1 INH
c. C9
d. MBL
C9
- no known disease association
which of the following deficient component is associated with paroxysmal nocturnal hemoglobinuria
A. C5-C8
b. C1 INH
c. C9
d. MIRL
MIRL and DAF
- PNH
first complement pathway being studies
a. classical
b. alternative
c. properdin
classical pathway
- fist complement pathway being studied
- initiated by antigen antibody binding
- recognition units ; C1q, C1r and C1s
- activation units : C4 , C2 and C3
- membrane attack complement : C5- C9
whgc ofthe following pathway bypass C1qrs , C4 and C2
a. classical
b. alternative
c. properdin
properdin / alternative pathway
- 1st complement being discovered
- bypass C1qrs, C4 and C2
