complement system Flashcards
acts as powerful opsonin
a. C3b
b. C5a
c. C3a
d. C5a
acts as powerful opsonin
- C3 b -> enhance of facilitate phagocytosis
acts as chemotaxin
- C5a
acts as anaphlatoxin
- C3a, C4a, and C5a -> promote inflammation
acts as chemotaxin
a. C3b
b. C5a
c. C3a
d. C5a
acts as powerful opsonin
- C3 b -> enhance of facilitate phagocytosis
acts as chemotaxin
- C5a
acts as anaphlatoxin
- C3a, C4a, and C5a -> promote inflammation
what are the electrolytes need for activation of complement
a. calcium
b. magnesium
c. chloride
d. potassium
ions involved
- Calcium and Magnesium
is a small polypetide that causes INCREASED VASCULAR PERMEABILITY, CONTRACTION OF SMOOTH MUSCLE AND RELEASE OF HISTAMINE from basophils and mast cell
a. opsonization
b. phagocytosis
c. anaphylatoxin
d. nota
anaphylatoxin
- small polypeptide
> causes :
increased vascular permeability
contraction of smooth muscle
release of histamine
in classical pathway :
binds to Fc of IgG and IgM
a. C1q
b. C1r
c. C1s
d. C4
c1q - binds to Fc of IgM and IgG
c1r - activates the C1s
C1s - cleaves C4 and C2
C4 - is part of c3 convertase (C4B)
in classical pathway:
it is KEY INTERMEDIATE TO ALL PATHWAY AND MOST CONCETRATED COMPLEMENT COMPONENT
a. c2
b. C3
c. C5
d. C6
c2 - binds to C4b - from C3 convertase
C3 - KEY INTERMEDIATE TO ALL PATHWAY AND MOST CONCETRATED COMPLEMENT COMPONENT
C5 - initiates MEMBRANE ATTACK COMPLEX (MAC)
in classical pathway
start to pore formation on membrane
a. c6
b. c7
c. c8
d. c9
c6 - BINDS TO c5B In MAC
C7 - binds to C5bC6 in MAC
c8 - start pore formation
c9 - polymerizes CELL LYSIS
alternative pathway
stabilizes C3 convertase and C5 convertase in the presence of magnesium
a. factor B
b. factor D
c. properdin
alternative pathway
Factor B
- binds C3B to from c3 convertase
Fcator D
- cleaves factor b
properdin
- stabilizes C3 convertase and C5 convertase in the presence of magnesium
MBL pathway
binds to mannose
a. MBL
b. MASP1
c. MASP2
MBL pathway
MBL
- binds to mannose
MASP -1
- helps to cleave C4 nad C@
MASP 2
- cleaves C4 and C2
which of the following deficient component is associated with athersclerosis
a. c2
b. c3
c. c4
d. c5-c8
C2
- lupus like syndrome
- recurrent infection
- ATHEROSCLEROSIS
- MOST COMMON DEFICIENCY
which of the following deficient component is associated with GLOMERULONEPHRITIS
a. c2
b. c3
c. c4
d. c5-c8
C3
- SEVERE RECURRENT INFECTION
- GLOMERULONEPHRITIS
- MOST SEVERE DEFICIENCY
which of the following deficient component is associated with NO KNOWN DISEASE
A. C5-C8
b. C1 INH
c. C9
d. MBL
C9
- no known disease association
which of the following deficient component is associated with paroxysmal nocturnal hemoglobinuria
A. C5-C8
b. C1 INH
c. C9
d. MIRL
MIRL and DAF
- PNH
first complement pathway being studies
a. classical
b. alternative
c. properdin
classical pathway
- fist complement pathway being studied
- initiated by antigen antibody binding
- recognition units ; C1q, C1r and C1s
- activation units : C4 , C2 and C3
- membrane attack complement : C5- C9
whgc ofthe following pathway bypass C1qrs , C4 and C2
a. classical
b. alternative
c. properdin
properdin / alternative pathway
- 1st complement being discovered
- bypass C1qrs, C4 and C2
what factor acts as a stabilizer for C3 convertase and c5 convetase in the presence of magnesium
a. Factor H
b. Factor P
c. Factor I
d. FActor B
properdin / alternative pathway
- 1st complement being discovered
- bypass C1qrs, C4 and C2
- originally thought to be initiated by properdin or factor P
- FACTOR P : acts as a stabilizer for C3 convertase and c5 convetase in the presence of magnesium
which of the following methods is most frequently used to measure INDIVIDUAL COMPONENTS
a. RIA
b. nephelometry
c. HEmolytic titraton assay
measure individual component
- radial immunodifusiom (RIA)
- nephelometry
measure individual COMPLEMENT COMPONENTS
- ELISA
it measures the amount of patient serum required to lyse 50% of stamderdized concentration of antibody sensitized sheep erythrocytes
a. RIA
b. nephelometry
c. HEmolytic titraton assay
Hemolytic titration assay
it measures the amount of patient serum required to lyse 50% of stamderdized concentration of antibody sensitized sheep erythrocytes
rabbit red blood cells that have been sensitized with antibody are implemented in agarose and patient serum is added to wells punched in the gel
a. hemolytic titration assay
b. radial hemolysis
c. elisa
radial hemolysis
- rabbit red blood cells that have been sensitized with antibody are implemented in agarose and patient serum is added to wells punched in the gel
- lysis appear as a clear zone around each wel
the best screen for complement abnormalities
a. hemolytic titration assay
b. radial hemolysis
c. elisa
hemolytic titration assay
- for functiion
ELISA
- best screen for complement abnormalities
