Nasopharyngeal Carcinoma Flashcards
1
Q
What are risk factors for the development of NPC?
A
Age
FHx
EBV infection
Fermented food and salted fish
Smoking
Chemical fumes
2
Q
What histological patterns can the disease present with?
A
Keratinizing squamous cell
Nonkeratinizing squamous cell carcinomas
Undifferentiated carcinomas with abundant non-neoplastic lymphocyte infiltrate
3
Q
How do NPCs present?
A
Primary NPCs are often clinically occult for long periods
70% present as metastasis to cervical LNs
Nasal symptoms - Bleeding, blockage, discharge
Ear - Deafness, infection, tinnitus
Cranial nerve palsy
Headaches
Neck swelling
4
Q
Why do you get hear deficits in NPC?
A
Extension of the tumour into the eustachian tube
