Lupus Flashcards

1
Q

How does OCP use relate to SLE?

A

OCP can cause a flare of SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the pathophysiology of Lupus?

A

Multisystem autoantibody attack and immune complex formation against products of apoptosis that are abnormally exposed to the immune system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What Ix can be used to monitor the activity of lupus and complications?

A

Activity

  • CRP, ESR
  • FBE - Hb and WBCs
  • Anti-ds-DNA antibody titres (ANA isn’t informative for activity)
  • UEC, MSU (kidneys)
  • Vitamin D
  • LFT
  • Complement C3 and C4 (not routine)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the name of the rash commonly seen in lupus?

A

Malar rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is SLE management medically?

A

Immunosuppresion:

  • Hydroxychloroquine
  • Steroids
  • Biologics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the antibodies specific to SLE that can be used from diagnosis?

A

Anti-RO

Anti-La

Anti-Smith

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the diagnostic criteria for lupus?

A

4+ of the following:

S - Serositis

O - Oral Ulcers

A - Arthritis/Athralgia

P - Photosensitivity

B - Blood disorder

R - Renal Impairment

A - ANA+

I - Anti-Smith, -Ro, -La

N - Neurological symptoms

M - Malar rash

D - Discoid rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the pattern of arthritis typically seen in SLE?

A

Symmetrical polyarthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the most common presenting signs and symptoms of SLE?

A

Arthritis

Malar rash

Fever

Fatigue

Renal impairment/proteinuria

Mouth Ulcers

Seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly