Nasal Drug Delivery Flashcards
1
Q
What are the 4 cell types in the respiratory epithelium?
A
Ciliated cells
Non ciliated cells
Goblet cells
Basal cells
2
Q
What are the 5 regions of the nose?
A
Vestibule Atrium Resp region with the inferior, middle and superior , turbinates Olfactory region Nasopharyx
3
Q
What are the mechanisms of drug absorption from the nasal cavity?
A
Passive diffusion
Transcytosis
Receptor mediated transport
4
Q
What are the advantages of nasal delivery for a systemic action?
A
Easy access Non invasive Avoids GiT Rapid absorption Easy formulation
5
Q
What are the disadvantages of nasal drug delivery?
A
Small cavity Mucociliary clearance Mucus barrier to absorption High levels of CYP450 and protease Nasal irritations Taste/ smell issues
