Allergy Flashcards
1
Q
How does an allergen cause a release of mediators of inflammation?
A
Allergen causes IgE synthesis
IgE attached to mast cell surface
Cross linking of IgE by allergen allowing calcium ions entry
Mast cell degranulation and release of mediators
2
Q
What are the clinical features of allergic rhinitis?
A
Nasal itching
Rhinorrhoea
Sneezing
Conjunctival symptoms
3
Q
Do antihistamines penetrate the BBB and have muscarnic side effects?
A
Yes to both
4
Q
How do decongestants work?
A
A- adrenoceptor agonists cause vasoconstriction
Reduce flow mucus
Act locally
5
Q
What is urticaria caused by?
A
Release of histamine
