Delivery Systems And Formulation For Inhalation Flashcards
What are the two types of nebulisers?
Jet
Ultrasonic
What are the advantages of using nebulisers?
No co-ordination
Large doses and mixture can be given
Cheap
Patient can see mist
What are the disadvantages of using nebulisers?
Not fully portable Equipment not regulated Lengthy nebulisation time Low efficiency Solution concentrates as water evaporates Insoluble drugs require solubilisation Microbial contamination
What is the role of a metering valve?
Accurate and reproducible volume of drug formulation is delivered
How can you increase inhalation of pDMI?
Spacer
Breath actuated
What are the advantages of pDMI?
Portable Robust Short treatment time Multi dose Uniformity Cheap
What are the disadvantages of pMDI?
Low lung deposition No dose counter Low doses Priming before use Performance depends on temp Drug formulation hard Not environmentally friendly
What are the main issues of DPI powder de-aggregation? How do we solve these?
Small particles cohesive
Moisture increase agglomeration
Solve - ordered mix
Spray dry
Protection form moisture e.g blister packs
What are the 3 types it DPI?
Unit dose devices
Multi unit dose devices
Reservoir devices
What are the advantages of DPI?
Portable Breath actuated no coordination Higher doses than pMDI dose counter Formulation easy to make Dry state more stable
What are the disadvantages of DPI?
Breath actuated depends on patients pressure Young children can't use Different devices Affected by humidity Expensive
What are the 3 types of inhalers?
Nebulisers
pMDI
DPI
