Inflammatory Bowel Disease

Question 1

What are the symptoms of Crohn’s disease?

Answer 1

Diarrhoea 
Pain 
Strictures and bowel obstruction 
Abscess formation 
Fistulisation to skin and internal organs

Question 2

What are strictures and how do they happen?

Answer 2

Inflammation leads to scar tissue formation

Is the narrowing of lumen and obstruction

Question 3

What are fistulae?

Answer 3

Ulcers which develop into tunnels

Question 4

What are the symptoms of ulcerative colitis?

Answer 4

Severe diarrhoea
Blood loss
Loss of peristaltic function
Toxic mega colon causing perforations and sepsis

Question 5

How does azathioprine inhibit purine synthesis?

Answer 5

By converting to mercaptopurine which inhibits purine synthesis

Question 6

When does Crohn’s disease effect?

Answer 6

Anywhere in GiT from mouth to anus