Adrenaline Chemistry Flashcards
1
Q
Where and what metabolises isoetharine?
A
Taken up by tissues and methylated by COMT
2
Q
How do you increase the bioavailability of adrenoceptor agonists?
A
Change OH group from benzene ring to HOCH2
3
Q
What does s enantiomer do to salbutamol metabolism?
A
S blocks metabolism of active R form
4
Q
What are the 6 steps of salbutamol synthesis?
A
Fries re-arrangement Esterification Bromination Nucleophilic sub Reduction Hydrogenolysis
5
Q
What is the starting compound for adrenaline and noradrenaline biosynthesis?
A
L-tyrosine
