myeloma Flashcards

1
Q

what

A

plasma cell proliferation

due to genetic mutations which occur as B Lymphocytes differentiate into mature plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

median age presentation

A

70

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CRABBI

A
hypercalcaemia 
renal disease
anaemia 
bleeding 
bone disease
infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

bloods show

A
anaemia 
thrombocytopenia
raised urea
raised creatinine 
raised calcium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

finding on peripheral blood film

A

rouleaux formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

serum or urine protein electrophoresis shows

A

serum - raised concentrations of monoclonal Ig

urine - bence jomes protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

common x-ray finding

A

rain-drop skull

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

induction Mx - suitable for autologous SCT

A

bortezomib + dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

induction Mx - unsuitable for autologous SCT

A

thalidomide + alkylating agent + dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mx - relapse

A

bortezomib monotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly