myeloma Flashcards
1
Q
what
A
plasma cell proliferation
due to genetic mutations which occur as B Lymphocytes differentiate into mature plasma cells
2
Q
median age presentation
A
70
3
Q
CRABBI
A
hypercalcaemia renal disease anaemia bleeding bone disease infection
4
Q
bloods show
A
anaemia thrombocytopenia raised urea raised creatinine raised calcium
5
Q
finding on peripheral blood film
A
rouleaux formation
6
Q
serum or urine protein electrophoresis shows
A
serum - raised concentrations of monoclonal Ig
urine - bence jomes protein
7
Q
common x-ray finding
A
rain-drop skull
8
Q
induction Mx - suitable for autologous SCT
A
bortezomib + dexamethasone
9
Q
induction Mx - unsuitable for autologous SCT
A
thalidomide + alkylating agent + dexamethasone
10
Q
Mx - relapse
A
bortezomib monotherapy