haemolytic anaemia

Question 1

intravascular haemolysis

Answer 1

occurs in blood stream

results in release of cellular contents into circulation

Question 2

causes of intravascular haemolysis

Answer 2

G6PD
autoimmune haemolytic anaemia 
acute transfusion rections
cardiac valves
microangiopathic haemolytic anaemia

Question 3

extravascular haemolysis

Answer 3

occurs in reticuloendothelial system

hepatosplenomegaly is typical

Question 4

causes of extravascular haemolysis

Answer 4

sickle cell anaemia

hereditary spherocytosis

Question 5

warm autoimmun haemolytic anaemia

Answer 5

IgG mediated

spleen tags cells for splenic phagocytosis

Question 6

warm autoimmun haemolytic anaemia - causes

Answer 6

idiopathic
CLL, lymphoma
drugs e.g. methyldopa
SLE

Question 7

cold autoimmun haemolytic anaemia

Answer 7

IgM mediated

IgM fixed complement causing direct intravscualr hameolyis

Question 8

cold autoimmun haemolytic anaemia - causes

Answer 8

idiopathic
post-infectious
lymphoma

Question 9

coombs negative harmolytic anaemia - causes

Answer 9

microangiopathic heamolytic anaemia 
paroxysmal nocturla haemoglobinuria 
HUS
malaria 
DIC