misc

Question 1

typical presentation beta thalassaemia major

Answer 1

new onset microcytic anaemia 3-9mo age
frontal bossing
hepatosplenomegaly

Question 2

blood results iron deficiency anaemia

Answer 2

low Hb
low MCV
low MCH
low ferritin 
inc total iron binding capacity

Question 3

features of transfusion related iron overload

Answer 3

joint pain

hyperpigmentation

Question 4

carbot rings on blood film indicate

Answer 4

pernicious anaemia

Question 5

Mx MALT lymphoma

Answer 5

PPI + amoxicillin + clarithromycin

triple therapy H.Pylori erradication

Question 6

dry tap - bone marrow apsiration

Answer 6

assoc with myelofibrosis

- it is difficult to aspirate bone marrow resulting in ‘dry tap’

Question 7

rouleax on blood film

Answer 7

multiple myeloma

Question 8

PT and APPT - Von-Willebrand disease

Answer 8

normal PT
prolonged APPT
low F8 activity levels

Question 9

type of autoantibody assoc with cold haemolytic anaemia

Answer 9

IgM

Question 10

autoantibody assoc with warm haemolytic anaemia

Answer 10

IgG

Question 11

sideroblasts on blood film indicate

Answer 11

myelodysplasia

Question 12

sickle cell - prophylaxis of painful crisis

Answer 12

hydroxyruea - stimulates HbF

Question 13

inheritance pattern - G6PD deficiency

Answer 13

x linked recessive

Question 14

inheritance pattern - hereditary spherocytosis

Answer 14

autosomal dominant

Question 15

Dx sickle cell disease

Answer 15

haemoglobin electrophoresis

Question 16

reed-steenberg cells

Answer 16

bilobed nucleus

prominent eosinophilic inclusion like nucleoli

Question 17

which blood product has highest risk bacterial contamination

Answer 17

platelets

Question 18

irradiated blood products

Answer 18

depleted of T lymphocytes

used to avoid transfusion assoc GvHD